On the scaling behavior of water diffusion in human brain white matter.
Neuroimage
; 185: 379-387, 2019 01 15.
Article
em En
| MEDLINE
| ID: mdl-30292815
ABSTRACT
Development of therapies for neurological disorders depends on our ability to non-invasively diagnose and monitor the progression of underlying pathologies at the cellular level. Physics and physiology limit the resolution of human MRI to be orders of magnitude coarser than cell dimensions. Here we identify and quantify the MRI signal coming from within micrometer-thin axons in human white matter tracts in vivo, by utilizing the sensitivity of diffusion MRI to Brownian motion of water molecules restricted by cell walls. We study a specific power-law scaling of the diffusion MRI signal with the diffusion weighting, predicted for water confined to narrow axons, and quantify axonal water fraction and orientation dispersion.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Processamento de Imagem Assistida por Computador
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Encéfalo
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Imagem de Difusão por Ressonância Magnética
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Neuroimagem
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Substância Branca
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Neuroimage
Assunto da revista:
DIAGNOSTICO POR IMAGEM
Ano de publicação:
2019
Tipo de documento:
Article