Translating Evidence of HDL and Plaque Regression.
Arterioscler Thromb Vasc Biol
; 38(9): 1961-1968, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-30354261
ABSTRACT
Considerable evidence from preclinical and population studies suggests that HDLs (high-density lipoproteins) possess atheroprotective properties. Reports from HDL infusion studies in animals and early clinical imaging trials reported evidence of plaque regression. These findings have stimulated further interest in developing new agents targeting HDL. However, the results of more recent imaging studies in the setting of high-intensity statin use have been disappointing. As the concept of plaque changes with HDL therapeutics evolves and imaging technology to evaluate these effects advances, there will become increasing opportunity to determine the effects of HDL agents on atherosclerotic plaque (Graphic Abstract).
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Placa Aterosclerótica
/
Lipoproteínas HDL
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Arterioscler Thromb Vasc Biol
Assunto da revista:
ANGIOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article