Doublecortin-Like Kinase 1 (DCLK1) Regulates B Cell-Specific Moloney Murine Leukemia Virus Insertion Site 1 (Bmi-1) and is Associated with Metastasis and Prognosis in Pancreatic Cancer.

Li, Jian; Wang, Yunchao; Ge, Jiayun; Li, Wenhua; Yin, Liangyu; Zhao, Zhiping; Liu, Songsong; Qin, Huan; Yang, Jiali; Wang, Lijiang; Ni, Bing; Liu, Yongkang; Wang, Huaizhi

Li, Jian; Wang, Yunchao; Ge, Jiayun; Li, Wenhua; Yin, Liangyu; Zhao, Zhiping; Liu, Songsong; Qin, Huan; Yang, Jiali; Wang, Lijiang; Ni, Bing; Liu, Yongkang; Wang, Huaizhi.

Afiliação

Li J; Institute of Hepatopancreatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China.
Wang Y; Department of General Surgery, 452 Hospital of PLA, Chengdu, China.
Ge J; Department of Pathophysiology and High Altitude Pathology, Third Military Medical University, Chongqing, China.
Li W; Institute of Hepatopancreatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China.
Yin L; Department of Hepatopancreatobiliary Surgery, The Second Hospital Affiliated Kunming Medical University, Kunming, China.
Zhao Z; Department of Cadre Ward, 452 Hospital of PLA, Chengdu, China.
Liu S; Institute of Hepatopancreatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China.
Qin H; Institute of Hepatopancreatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China.
Yang J; Institute of Hepatopancreatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China.
Wang L; Institute of Hepatopancreatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China.
Ni B; Institute of Hepatopancreatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China.
Liu Y; Gulliver Preparatory School, Miami, Florida, USA.
Wang H; Department of Pathophysiology and High Altitude Pathology, Third Military Medical University, Chongqing, China.

Cell Physiol Biochem ; 51(1): 262-277, 2018.

Article em En | MEDLINE | ID: mdl-30453285

Assuntos

Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Neoplasias Pancreáticas/patologia; Complexo Repressor Polycomb 1/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Animais; Caderinas/metabolismo; Linhagem Celular Tumoral; Movimento Celular; Proliferação de Células; Quinases Semelhantes a Duplacortina; Transição Epitelial-Mesenquimal; Regulação da Expressão Gênica; Humanos; Peptídeos e Proteínas de Sinalização Intracelular/antagonistas & inibidores; Peptídeos e Proteínas de Sinalização Intracelular/genética; Estimativa de Kaplan-Meier; Camundongos; Camundongos Nus; Células-Tronco Neoplásicas/citologia; Células-Tronco Neoplásicas/metabolismo; Neoplasias Pancreáticas/tratamento farmacológico; Neoplasias Pancreáticas/mortalidade; Prognóstico; Proteínas Serina-Treonina Quinases/antagonistas & inibidores; Proteínas Serina-Treonina Quinases/genética; Interferência de RNA; RNA Interferente Pequeno/metabolismo; RNA Interferente Pequeno/uso terapêutico; Fatores de Transcrição da Família Snail/metabolismo; Vimentina/metabolismo

Palavras-chave

DCLK1; EMT; Metastasis; Pancreatic cancer; Prognosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Proteínas Serina-Treonina Quinases / Peptídeos e Proteínas de Sinalização Intracelular / Complexo Repressor Polycomb 1 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Cell Physiol Biochem Assunto da revista: BIOQUIMICA / FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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