Maternal occupational exposures to nanoscale particles and small for gestational age outcome in the French Longitudinal Study of Children.
Environ Int
; 122: 322-329, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30459064
ABSTRACT
OBJECTIVES:
To investigate the association between maternal occupational exposures to nanoscale particles (NPs) during pregnancy and small for gestational age (SGA).METHODS:
This study included 11,224 mothers and singleton birth pairs from the French Longitudinal Study of Children (ELFE cohort), which included infants born after 33â¯weeks of gestation or more in continental France in 2011. Mothers who did not work during pregnancy were excluded from the analyses. Maternal occupational exposures to NPs was estimated using a job-exposure matrix for the probability (>50% occupationally exposed group, nâ¯=â¯569; 0% occupationally non-exposed group, nâ¯=â¯9113; between these two thresholds uncertain group, nâ¯=â¯1542) and frequency of exposure. Associations were estimated from multivariate logistic regression models for occupationally exposed vs occupationally unexposed groups in a first analysis, and with the frequency-weighted duration of work for the occupationally exposed group only in a second analysis.RESULTS:
Among working mothers, 5.1% were occupationally exposed to NPs. Maternal occupational exposures to NPs was associated with SGA (ORaâ¯=â¯1.63, 95% CI 1.22, 2.18). The frequency-weighted duration of work for the occupationally exposed group (nâ¯=â¯569) was not associated with SGA (ORaâ¯=â¯1.02, 95% CI 0.97, 1.08) in adjusted analyses.CONCLUSIONS:
These results, showing a significant association between occupational exposures to NPs and SGA, should encourage further studies to examine the adverse effect of NPs exposure on fetal development.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Pequeno para a Idade Gestacional
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Exposição Ocupacional
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Exposição Materna
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Material Particulado
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Nanopartículas
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Newborn
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Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Revista:
Environ Int
Ano de publicação:
2019
Tipo de documento:
Article