Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines: An update comprising flunitrazolam, norflurazepam, and 4'-chlorodiazepam (Ro5-4864).

Moosmann, Bjoern; Bisel, Philippe; Westphal, Folker; Wilde, Maurice; Kempf, Jürgen; Angerer, Verena; Auwärter, Volker

Moosmann, Bjoern; Bisel, Philippe; Westphal, Folker; Wilde, Maurice; Kempf, Jürgen; Angerer, Verena; Auwärter, Volker.

Afiliação

Moosmann B; Institute of Forensic Medicine, Forensic Toxicology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Bisel P; Institute of Forensic Medicine, Forensic Toxicology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Westphal F; Institute of Pharmaceutical Sciences, University of Freiburg, Freiburg, Germany.
Wilde M; State Bureau of Criminal Investigation Schleswig-Holstein, Kiel, Germany.
Kempf J; Institute of Forensic Medicine, Forensic Toxicology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Angerer V; Hermann Staudinger Graduate School, University of Freiburg, Freiburg, Germany.
Auwärter V; Institute of Forensic Medicine, Forensic Toxicology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Drug Test Anal ; 11(3): 541-549, 2019 Mar.

Article em En | MEDLINE | ID: mdl-30578721

Assuntos

Benzodiazepinas/metabolismo; Benzodiazepinonas/metabolismo; Drogas Desenhadas/metabolismo; Flurazepam/análogos & derivados; Desintoxicação Metabólica Fase I; Microssomos Hepáticos/metabolismo; Biotransformação; Cromatografia Líquida; Flurazepam/metabolismo; Cromatografia Gasosa-Espectrometria de Massas; Humanos; Técnicas In Vitro; Detecção do Abuso de Substâncias/métodos; Espectrometria de Massas em Tandem

Palavras-chave

LC-MS/MS; desalkylflurazepam; legal highs; new psychoactive substances; norfludiazepam

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzodiazepinas / Benzodiazepinonas / Microssomos Hepáticos / Drogas Desenhadas / Desintoxicação Metabólica Fase I / Flurazepam Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Drug Test Anal Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suíça

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