Immunological methods for the diagnosis of oral mucosal diseases.
Br J Dermatol
; 181(1): 23-36, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-30585301
ABSTRACT
Immunological methods, which have been widely used in autoimmune blistering diseases (AIBDs) of the oral mucosa, can also be adopted as auxiliary diagnostic tools in oral lichen planus (OLP) and discoid lupus erythematosus (DLE). AIBDs, characterized by autoantibodies against structural proteins of keratinocytes or the basement membrane zone, clinically present as blisters and erosions of the oral mucosa. When atypical lesions occur, OLP or DLE may be confused with AIBDs. The improvement of diagnostic accuracy is necessary due to the significant differences in treatment and prognosis among these diseases. A variety of immunological methods are used for qualitative and quantitative detection of target antigens and autoantibodies. These methods can evaluate efficacy of treatment, monitor diseases and guide treatment decisions. In this review, we discuss the application of immunofluorescence, biochemical tests, and protein microarrays for AIBDs, OLP and DLE, as well as the differential diagnostic methods using immunological tests.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Testes Imunológicos
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Técnicas de Preparação Histocitológica
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Doenças da Boca
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Mucosa Bucal
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
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Qualitative_research
Limite:
Humans
Idioma:
En
Revista:
Br J Dermatol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China