Your browser doesn't support javascript.
loading
Ten-Year Comparison Study of Type 1 and 2 Endometrial Cancers: Risk Factors and Outcomes.
Feinberg, Jacqueline; Albright, Benjamin; Black, Jonathan; Lu, Lingeng; Passarelli, Rachel; Gysler, Stefan; Whicker, Margaret; Altwerger, Gary; Menderes, Gulden; Hui, Pei; Santin, Alessandro D; Azodi, Masoud; Silasi, Dan-Arin; Ratner, Elena S; Litkouhi, Babak; Schwartz, Peter E.
Afiliação
  • Feinberg J; Yale University School of Medicine, New Haven, Connecticut, USA, jackie.feinberg@yale.edu.
  • Albright B; Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Black J; Yale University School of Medicine, New Haven, Connecticut, USA.
  • Lu L; Yale University School of Medicine, New Haven, Connecticut, USA.
  • Passarelli R; Yale University School of Medicine, New Haven, Connecticut, USA.
  • Gysler S; Yale University School of Medicine, New Haven, Connecticut, USA.
  • Whicker M; Yale University School of Medicine, New Haven, Connecticut, USA.
  • Altwerger G; Yale University School of Medicine, New Haven, Connecticut, USA.
  • Menderes G; Yale University School of Medicine, New Haven, Connecticut, USA.
  • Hui P; Yale University School of Medicine, New Haven, Connecticut, USA.
  • Santin AD; Yale University School of Medicine, New Haven, Connecticut, USA.
  • Azodi M; Yale University School of Medicine, New Haven, Connecticut, USA.
  • Silasi DA; Yale University School of Medicine, New Haven, Connecticut, USA.
  • Ratner ES; Yale University School of Medicine, New Haven, Connecticut, USA.
  • Litkouhi B; Yale University School of Medicine, New Haven, Connecticut, USA.
  • Schwartz PE; Yale University School of Medicine, New Haven, Connecticut, USA.
Gynecol Obstet Invest ; 84(3): 290-297, 2019.
Article em En | MEDLINE | ID: mdl-30602164
AIMS: To compare baseline risk factors for type 1 vs. 2 endometrial cancers and analyze these risk factors for association with overall survival and time to recurrence. METHODS: Retrospective review of 816 consecutive endometrial cancer cases was conducted with diagnosis from January 2005 to December 2010 and clinical course until 2016. Risk factors, treatment, recurrence, and death were compared using 2 sample t tests, χ2 test and Cox Regression models. RESULTS: There were 550 cases of type 1 and 266 cases of type 2 cancer. Patients with type 2 disease were older (p < 0.001), less obese (p = 0.03), non-white (p < 0.001), and menopausal (p = 0.02). There was no difference in use of oral contraceptives, hormone replacement therapy (HRT), smoking, or major cardiovascular disease. Cox Regression models showed that type 2 disease (p < 0.001) and advanced stage (p = 0.001) were associated with recurrence. CONCLUSIONS: Consistent with previous literature, our analysis found that type 2 cancer is more common in non-white, older, and less obese patients and associated with higher mortality and recurrence. However, inconsistent with previous literature, we found no association between type 2 cancer and diabetes mellitus or use of HRT. These factors should be considered when approaching patients with endometrial cancer.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Gynecol Obstet Invest Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Gynecol Obstet Invest Ano de publicação: 2019 Tipo de documento: Article