CP­31398 attenuates endometrial cancer cell invasion, metastasis and resistance to apoptosis by downregulating MDM2 expression.

Liu, Ling; Yang, Li; Chang, Hui; Chen, Yan-Nan; Zhang, Feng; Feng, Shuo; Peng, Juan; Ren, Chen-Chen; Zhang, Xiao-An

CP31398 attenuates endometrial cancer cell invasion, metastasis and resistance to apoptosis by downregulating MDM2 expression.

Liu, Ling; Yang, Li; Chang, Hui; Chen, Yan-Nan; Zhang, Feng; Feng, Shuo; Peng, Juan; Ren, Chen-Chen; Zhang, Xiao-An.

Afiliação

Liu L; Department of Gynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Yang L; Department of Gynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Chang H; Laboratory of Tumor Precision Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Chen YN; Department of Gynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Zhang F; Department of Gynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Feng S; Department of Gynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Peng J; Department of Gynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Ren CC; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Zhang XA; Department of Imaging, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

Int J Oncol ; 54(3): 942-954, 2019 03.

Article em En | MEDLINE | ID: mdl-30628640

Assuntos

Regulação para Baixo/efeitos dos fármacos; Neoplasias do Endométrio/patologia; Proteínas Proto-Oncogênicas c-mdm2/genética; Pirimidinas/farmacologia; Adulto; Idoso; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Neoplasias do Endométrio/metabolismo; Feminino; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Concentração Inibidora 50; Pessoa de Meia-Idade; Invasividade Neoplásica; Proteínas Proto-Oncogênicas c-mdm2/metabolismo; RNA Mensageiro/metabolismo; RNA Interferente Pequeno/farmacologia

Palavras-chave

CP-31398; murine double minute 2; endometrial cancer; apoptosis; migration; invasion

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Regulação para Baixo / Neoplasias do Endométrio / Proteínas Proto-Oncogênicas c-mdm2 Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Int J Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article

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