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Probucol ameliorates hepatic stellate cell activation and autophagy is associated with farnesoid X receptor.
Yang, Ruhui; Hu, Zhiyong; Zhang, Pengyong; Wu, Songquan; Song, Zhaoxia; Shen, Xiangchun; Wei, Zhe.
Afiliação
  • Yang R; Department of Pharmacology, College of Medicine and Health, Lishui University, Lishui, 323000, China.
  • Hu Z; School of Public Health, Soochow University, Suzhou, 215123, China.
  • Zhang P; Tancheng County Health and Family Planning Law Enforcement and Supervision Team, Linyi, 276100, China.
  • Wu S; Department of Pharmacology, College of Medicine and Health, Lishui University, Lishui, 323000, China.
  • Song Z; Department of Obstetrics, Lishui Maternal and Child Health Hospital, Lishui, 323000, China.
  • Shen X; The Department of Pharmacology of Materia Medica (The State Key Laboratory of Functions and Applications of Medicinal Plants, The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, The Key Laboratory of Optimal Utilization of Natural Medicine Resources),
  • Wei Z; Department of Pharmacology, College of Medicine and Health, Lishui University, Lishui, 323000, China. Electronic address: weizhe315@126.com.
J Pharmacol Sci ; 139(2): 120-128, 2019 Feb.
Article em En | MEDLINE | ID: mdl-30638990
Probucol has antioxidant effects and inhibits inflammation. Farnesoid X receptor (FXR) is a nuclear receptor that regulates autophagy, which is regarded as the key cause of the activation of hepatic stellate cell (HSC). In this study, the effects of probucol on HSC activation and autophagy in vitro and vivo and the role of FXR in this progress were investigated. Results showed that probucol ameliorated hepatic fibrosis and autophagy, and increased the expression of FXR in liver in a mouse model of fibrosis induced by CCl4. And probucol could alleviate lipopolysaccharide-induced autophagy and HSC activation in vitro. In addition, probucol increased FXR expression, and the Z-guggulsterone, an antagonist of FXR, could block the effects of probucol on HSC activation and autophagy. Additionally, agonists of FXR could suppress LPS-induced autophagy and activation. These results suggest that probucol could ameliorate hepatic fibrosis, and inhibit HSC autophagy and activation, and these effects are associated with FXR.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Probucol / Receptores Citoplasmáticos e Nucleares / Células Estreladas do Fígado / Antioxidantes Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: J Pharmacol Sci Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Probucol / Receptores Citoplasmáticos e Nucleares / Células Estreladas do Fígado / Antioxidantes Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: J Pharmacol Sci Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China