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Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death.
Simmons, Ambrosia J; Park, Raehee; Sterling, Noelle A; Jang, Mi-Hyeon; van Deursen, Jan M A; Yen, Timothy J; Cho, Seo-Hee; Kim, Seonhee.
Afiliação
  • Simmons AJ; Shriners Hospitals Pediatric Research Center, Department of Anatomy and Cell Biology, Lewis Katz School of Medicine Temple University, Philadelphia, PA, USA.
  • Park R; MD/Ph.D. program, Lewis Katz School of Medicine Temple University, Philadelphia, PA, USA.
  • Sterling NA; Shriners Hospitals Pediatric Research Center, Department of Anatomy and Cell Biology, Lewis Katz School of Medicine Temple University, Philadelphia, PA, USA.
  • Jang MH; Shriners Hospitals Pediatric Research Center, Department of Anatomy and Cell Biology, Lewis Katz School of Medicine Temple University, Philadelphia, PA, USA.
  • van Deursen JMA; Department of Neurologic Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA.
  • Yen TJ; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA.
  • Cho SH; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA.
  • Kim S; Fox Chase Cancer Center, Philadelphia, PA, USA.
Hum Mol Genet ; 28(11): 1822-1836, 2019 06 01.
Article em En | MEDLINE | ID: mdl-30668728
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Proteínas de Ciclo Celular / Neurogênese / Microcefalia / Mitose Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Hum Mol Genet Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Proteínas de Ciclo Celular / Neurogênese / Microcefalia / Mitose Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Hum Mol Genet Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos