Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator.

Abdallah, Abdallah M; Weerdenburg, Eveline M; Guan, Qingtian; Ummels, Roy; Borggreve, Stephanie; Adroub, Sabir A; Malas, Tareq B; Naeem, Raeece; Zhang, Huoming; Otto, Thomas D; Bitter, Wilbert; Pain, Arnab

Abdallah, Abdallah M; Weerdenburg, Eveline M; Guan, Qingtian; Ummels, Roy; Borggreve, Stephanie; Adroub, Sabir A; Malas, Tareq B; Naeem, Raeece; Zhang, Huoming; Otto, Thomas D; Bitter, Wilbert; Pain, Arnab.

Afiliação

Abdallah AM; Pathogen Genomics Laboratory, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal-Jeddah, Kingdom of Saudi Arabia.
Weerdenburg EM; Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands.
Guan Q; Pathogen Genomics Laboratory, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal-Jeddah, Kingdom of Saudi Arabia.
Ummels R; Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands.
Borggreve S; Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands.
Adroub SA; Pathogen Genomics Laboratory, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal-Jeddah, Kingdom of Saudi Arabia.
Malas TB; Pathogen Genomics Laboratory, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal-Jeddah, Kingdom of Saudi Arabia.
Naeem R; Pathogen Genomics Laboratory, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal-Jeddah, Kingdom of Saudi Arabia.
Zhang H; Bioscience Core Laboratory, King Abdullah University of Science and Technology (KAUST), Thuwal-Jeddah, Kingdom of Saudi Arabia.
Otto TD; Pathogen Genomics, The Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.
Bitter W; Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands.
Pain A; Pathogen Genomics Laboratory, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal-Jeddah, Kingdom of Saudi Arabia.

PLoS One ; 14(1): e0211003, 2019.

Article em En | MEDLINE | ID: mdl-30673778

Assuntos

Antígenos de Bactérias; Proteínas de Bactérias; Regulação para Baixo; Regulação Bacteriana da Expressão Gênica; Mycobacterium marinum; Mycobacterium tuberculosis; Transcriptoma; Antígenos de Bactérias/genética; Antígenos de Bactérias/metabolismo; Proteínas de Bactérias/genética; Proteínas de Bactérias/metabolismo; Humanos; Mutação; Mycobacterium marinum/genética; Mycobacterium marinum/metabolismo; Mycobacterium tuberculosis/genética; Mycobacterium tuberculosis/metabolismo; Células THP-1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Regulação para Baixo / Regulação Bacteriana da Expressão Gênica / Mycobacterium marinum / Transcriptoma / Mycobacterium tuberculosis / Antígenos de Bactérias Limite: Humans Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2019 Tipo de documento: Article

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