Acetyltransferase p300 inhibitor reverses hypertension-induced cardiac fibrosis.

Rai, Rahul; Sun, Tianjiao; Ramirez, Veronica; Lux, Elizabeth; Eren, Mesut; Vaughan, Douglas E; Ghosh, Asish K

Rai, Rahul; Sun, Tianjiao; Ramirez, Veronica; Lux, Elizabeth; Eren, Mesut; Vaughan, Douglas E; Ghosh, Asish K.

Afiliação

Rai R; Feinberg School of Medicine, Feinberg Cardiovascular and Renal Research Institute, Northwestern University, Chicago, IL.
Sun T; Feinberg School of Medicine, Feinberg Cardiovascular and Renal Research Institute, Northwestern University, Chicago, IL.
Ramirez V; Feinberg School of Medicine, Feinberg Cardiovascular and Renal Research Institute, Northwestern University, Chicago, IL.
Lux E; Feinberg School of Medicine, Feinberg Cardiovascular and Renal Research Institute, Northwestern University, Chicago, IL.
Eren M; Feinberg School of Medicine, Feinberg Cardiovascular and Renal Research Institute, Northwestern University, Chicago, IL.
Vaughan DE; Feinberg School of Medicine, Feinberg Cardiovascular and Renal Research Institute, Northwestern University, Chicago, IL.
Ghosh AK; Feinberg School of Medicine, Feinberg Cardiovascular and Renal Research Institute, Northwestern University, Chicago, IL.

J Cell Mol Med ; 23(4): 3026-3031, 2019 04.

Article em En | MEDLINE | ID: mdl-30710427

Assuntos

Benzoatos/farmacologia; Cardiomegalia/prevenção & controle; Fibrose/prevenção & controle; Inibidores de Histona Desacetilases/farmacologia; Hipertensão/complicações; Pirazóis/farmacologia; Fatores de Transcrição de p300-CBP/antagonistas & inibidores; Acetilação; Animais; Cardiomegalia/etiologia; Cardiomegalia/metabolismo; Cardiomegalia/patologia; Células Cultivadas; Fibrose/etiologia; Fibrose/metabolismo; Fibrose/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Nitrobenzenos; Pirazolonas

Palavras-chave

acetyltransferase p300; cardiac fibrosis; cardiac hypertrophy; collagens; epigenetics; hypertension; small molecule inhibitors of p300

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Benzoatos / Fibrose / Cardiomegalia / Fatores de Transcrição de p300-CBP / Inibidores de Histona Desacetilases / Hipertensão Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: J Cell Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Israel

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