Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts.

Wang, Huabo; Lu, Jie; Kulkarni, Sucheta; Zhang, Weiqi; Gorka, Joanna E; Mandel, Jordan A; Goetzman, Eric S; Prochownik, Edward V

Wang, Huabo; Lu, Jie; Kulkarni, Sucheta; Zhang, Weiqi; Gorka, Joanna E; Mandel, Jordan A; Goetzman, Eric S; Prochownik, Edward V.

Afiliação

Wang H; From the Section of Hematology/Oncology and.
Lu J; From the Section of Hematology/Oncology and.
Kulkarni S; From the Section of Hematology/Oncology and.
Zhang W; From the Section of Hematology/Oncology and.
Gorka JE; From the Section of Hematology/Oncology and.
Mandel JA; From the Section of Hematology/Oncology and.
Goetzman ES; Division of Medical Genetics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania 15224.
Prochownik EV; From the Section of Hematology/Oncology and procev@chp.edu.

J Biol Chem ; 294(14): 5466-5486, 2019 04 05.

Article em En | MEDLINE | ID: mdl-30755479

Assuntos

Ciclo do Ácido Cítrico; Fibroblastos/metabolismo; Potencial da Membrana Mitocondrial; Consumo de Oxigênio; Complexo Piruvato Desidrogenase/genética; Animais; Linhagem Celular Tumoral; Proliferação de Células; Fibroblastos/patologia; Humanos; Complexo Piruvato Desidrogenase/metabolismo; Ratos; Ratos Mutantes

Palavras-chave

Myc (c-Myc); Warburg effect; fatty acid oxidation; glutaminolysis; pyruvate carboxylase (PC); reverse carboxylation; tricarboxylic acid cycle (TCA cycle) (Krebs cycle)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Consumo de Oxigênio / Complexo Piruvato Desidrogenase / Ciclo do Ácido Cítrico / Potencial da Membrana Mitocondrial / Fibroblastos Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article

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