A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma.

Hayes, Tikvah K; Luo, Flora; Cohen, Ofir; Goodale, Amy B; Lee, Yenarae; Pantel, Sasha; Bagul, Mukta; Piccioni, Federica; Root, David E; Garraway, Levi A; Meyerson, Matthew; Johannessen, Cory M

Hayes, Tikvah K; Luo, Flora; Cohen, Ofir; Goodale, Amy B; Lee, Yenarae; Pantel, Sasha; Bagul, Mukta; Piccioni, Federica; Root, David E; Garraway, Levi A; Meyerson, Matthew; Johannessen, Cory M.

Afiliação

Hayes TK; Department of Medical Oncology, Dana-Farber Cancer Institute & Harvard Medical School, Boston, Massachusetts.
Luo F; Cancer Program, The Broad Institute of M.I.T. and Harvard, Cambridge, Massachusetts.
Cohen O; Department of Medical Oncology, Dana-Farber Cancer Institute & Harvard Medical School, Boston, Massachusetts.
Goodale AB; Cancer Program, The Broad Institute of M.I.T. and Harvard, Cambridge, Massachusetts.
Lee Y; Department of Medical Oncology, Dana-Farber Cancer Institute & Harvard Medical School, Boston, Massachusetts.
Pantel S; Cancer Program, The Broad Institute of M.I.T. and Harvard, Cambridge, Massachusetts.
Bagul M; Genetic Perturbation Platform, The Broad Institute of M.I.T. and Harvard, Cambridge, Massachusetts.
Piccioni F; Genetic Perturbation Platform, The Broad Institute of M.I.T. and Harvard, Cambridge, Massachusetts.
Root DE; Genetic Perturbation Platform, The Broad Institute of M.I.T. and Harvard, Cambridge, Massachusetts.
Garraway LA; Genetic Perturbation Platform, The Broad Institute of M.I.T. and Harvard, Cambridge, Massachusetts.
Meyerson M; Genetic Perturbation Platform, The Broad Institute of M.I.T. and Harvard, Cambridge, Massachusetts.
Johannessen CM; Genetic Perturbation Platform, The Broad Institute of M.I.T. and Harvard, Cambridge, Massachusetts.

Cancer Res ; 79(9): 2352-2366, 2019 05 01.

Article em En | MEDLINE | ID: mdl-30819666

Assuntos

Quinase 4 Dependente de Ciclina/antagonistas & inibidores; Quinase 6 Dependente de Ciclina/antagonistas & inibidores; Resistencia a Medicamentos Antineoplásicos/genética; GTP Fosfo-Hidrolases/genética; MAP Quinase Quinase 1/antagonistas & inibidores; MAP Quinase Quinase 2/antagonistas & inibidores; Melanoma/tratamento farmacológico; Proteínas de Membrana/genética; Mutação; Antineoplásicos/farmacologia; Apoptose; Pontos de Checagem do Ciclo Celular; Proliferação de Células; Humanos; Melanoma/genética; Melanoma/patologia; Fosforilação; Transdução de Sinais/efeitos dos fármacos; Células Tumorais Cultivadas

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistencia a Medicamentos Antineoplásicos / MAP Quinase Quinase 1 / MAP Quinase Quinase 2 / Quinase 4 Dependente de Ciclina / Quinase 6 Dependente de Ciclina / GTP Fosfo-Hidrolases / Melanoma / Proteínas de Membrana / Mutação Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cancer Res Ano de publicação: 2019 Tipo de documento: Article

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