Mir-455-3p-1 represses FGF7 expression to inhibit pulmonary arterial hypertension through inhibiting the RAS/ERK signaling pathway.

Zhou, Chenghui; Chen, Yu; Kang, Wenying; Lv, Hong; Fang, Zhongrong; Yan, Fuxia; Li, Lihuan; Zhang, Weili; Shi, Jia

Zhou, Chenghui; Chen, Yu; Kang, Wenying; Lv, Hong; Fang, Zhongrong; Yan, Fuxia; Li, Lihuan; Zhang, Weili; Shi, Jia.

Afiliação

Zhou C; Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China.
Chen Y; State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China.
Kang W; Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China.
Lv H; Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China.
Fang Z; Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China.
Yan F; Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China.
Li L; Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China.
Zhang W; State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China. Electronic address: zhangweili1747@yahoo.com.
Shi J; Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China. Electronic address: shijia@fuwai.com.

J Mol Cell Cardiol ; 130: 23-35, 2019 05.

Article em En | MEDLINE | ID: mdl-30858037

Assuntos

Fator 7 de Crescimento de Fibroblastos/biossíntese; Regulação da Expressão Gênica; Sistema de Sinalização das MAP Quinases; MicroRNAs/metabolismo; Proteína Oncogênica p21(ras)/metabolismo; Hipertensão Arterial Pulmonar/metabolismo; Animais; Linhagem Celular; Modelos Animais de Doenças; Humanos; Masculino; Hipertensão Arterial Pulmonar/patologia; Ratos

Palavras-chave

ERK; FGF7; PAH; RAS; miR-455-3p-1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Oncogênica p21(ras) / Regulação da Expressão Gênica / Sistema de Sinalização das MAP Quinases / MicroRNAs / Fator 7 de Crescimento de Fibroblastos / Hipertensão Arterial Pulmonar Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: J Mol Cell Cardiol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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