Overexpression of CD 133 and BCL-2 in non-small cell lung cancer with neuroendocrine differentiation after transformation in ALK rearrangement-positive adenocarcinoma.

Koyama, Kiyoko; Katsurada, Naoko; Jimbo, Naoe; Tachihara, Motoko; Tamura, Daisuke; Nakata, Kyosuke; Nagano, Tatsuya; Yamamoto, Masatsugu; Kamiryo, Hiroshi; Kobayashi, Kazuyuki; Itoh, Tomoo; Nishimura, Yoshihiro

Koyama, Kiyoko; Katsurada, Naoko; Jimbo, Naoe; Tachihara, Motoko; Tamura, Daisuke; Nakata, Kyosuke; Nagano, Tatsuya; Yamamoto, Masatsugu; Kamiryo, Hiroshi; Kobayashi, Kazuyuki; Itoh, Tomoo; Nishimura, Yoshihiro.

Afiliação

Koyama K; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Katsurada N; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Jimbo N; Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.
Tachihara M; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Tamura D; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Nakata K; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Nagano T; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Yamamoto M; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Kamiryo H; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Kobayashi K; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Itoh T; Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.
Nishimura Y; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Pathol Int ; 69(5): 294-299, 2019 May.

Article em En | MEDLINE | ID: mdl-30900377

Assuntos

Adenocarcinoma de Pulmão/terapia; Quinase do Linfoma Anaplásico/genética; Carbazóis/uso terapêutico; Carcinoma Pulmonar de Células não Pequenas; Piperidinas/uso terapêutico; Adenocarcinoma de Pulmão/genética; Adenocarcinoma de Pulmão/patologia; Adulto; Quinase do Linfoma Anaplásico/metabolismo; Antígenos CD/metabolismo; Biomarcadores Tumorais/metabolismo; Carbazóis/efeitos adversos; Carcinoma Pulmonar de Células não Pequenas/genética; Carcinoma Pulmonar de Células não Pequenas/metabolismo; Carcinoma Pulmonar de Células não Pequenas/patologia; Carcinoma Pulmonar de Células não Pequenas/secundário; Transformação Celular Neoplásica/genética; Transformação Celular Neoplásica/metabolismo; Feminino; Rearranjo Gênico; Humanos; Recidiva Local de Neoplasia; Células-Tronco Neoplásicas/metabolismo; Piperidinas/efeitos adversos; Inibidores de Proteínas Quinases/efeitos adversos; Inibidores de Proteínas Quinases/uso terapêutico; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Proteínas Repressoras/metabolismo; Fatores de Transcrição SOXB1/metabolismo

Palavras-chave

ALK rearrangement-positive lung cancer; adenocarcinoma; cancer stem cell; neuroendocrine carcinoma; small cell lung cancer; transformation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Carbazóis / Carcinoma Pulmonar de Células não Pequenas / Adenocarcinoma de Pulmão / Quinase do Linfoma Anaplásico Limite: Adult / Female / Humans Idioma: En Revista: Pathol Int Assunto da revista: PATOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão

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