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Membrane metalloprotease TRABD2A restricts HIV-1 progeny production in resting CD4+ T cells by degrading viral Gag polyprotein.
Liang, Guoxin; Zhao, Li; Qiao, Ying; Geng, Wenqing; Zhang, Xiaowei; Liu, Mei; Dong, Jinxiu; Ding, Haibo; Sun, Hong; Shang, Hong.
Afiliação
  • Liang G; Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang, China. gxliang@cmu.edu.cn.
  • Zhao L; Key Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, China. gxliang@cmu.edu.cn.
  • Qiao Y; Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang, China.
  • Geng W; Key Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, China.
  • Zhang X; The Core Laboratory for Public Health Science and Practice, The First Affiliated Hospital, China Medical University, Shenyang, China.
  • Liu M; Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang, China.
  • Dong J; Key Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, China.
  • Ding H; The Core Laboratory for Public Health Science and Practice, The First Affiliated Hospital, China Medical University, Shenyang, China.
  • Sun H; Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang, China.
  • Shang H; Key Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, China.
Nat Immunol ; 20(6): 711-723, 2019 06.
Article em En | MEDLINE | ID: mdl-31061530
Resting CD4+ T cells are highly resistant to the production of human immunodeficiency virus type 1 (HIV-1). However, the mechanism by which resting CD4+ T cells restrict such production in the late viral replication phase of infection has remained unclear. In this study, we found that the cell membrane metalloprotease TRAB domain-containing protein 2A (TRABD2A) inhibited this production in resting CD4+ T cells by degrading the virion structural precursor polyprotein Gag at the plasma membrane. Depletion or inhibition of metalloprotease activity by TRABD2A profoundly enhanced HIV-1 production in resting CD4+ T cells. TRABD2A expression was much higher in resting CD4+ T cells than in activated CD4+ T cells and was considerably reduced by T cell activation. Moreover, reexpressing TRABD2A reinforced the resistance of activated CD4+ T cells to the production of HIV-1 progeny. Collectively, these results elucidate the molecular mechanism employed by resting CD4+ T cells to potently restrict the assembly and production of HIV-1 progeny.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Replicação Viral / Linfócitos T CD4-Positivos / Infecções por HIV / HIV-1 / Metaloproteases / Produtos do Gene gag do Vírus da Imunodeficiência Humana Limite: Animals / Humans Idioma: En Revista: Nat Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Replicação Viral / Linfócitos T CD4-Positivos / Infecções por HIV / HIV-1 / Metaloproteases / Produtos do Gene gag do Vírus da Imunodeficiência Humana Limite: Animals / Humans Idioma: En Revista: Nat Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China