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A safety, pharmacokinetic, pharmacogenomic and population pharmacokinetic analysis of the third-generation EGFR TKI, olmutinib (HM61713), after single oral administration in healthy volunteers.
Noh, Young Su; Yoon, Seonghae; Kim, Suk Ran; Lee, Kyung-Tae; Jang, In-Jin.
Afiliação
  • Noh YS; Department of Fundamental Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, Korea.
  • Yoon S; Clinical Trials Center, Seoul National University Bundang Hospital, Seoul, Korea.
  • Kim SR; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea.
  • Lee KT; Clinical Research and Development, Hanmi Pharmaceutical Co., Ltd., Seoul, Korea.
  • Jang IJ; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul, Korea.
Basic Clin Pharmacol Toxicol ; 125(4): 370-381, 2019 Oct.
Article em En | MEDLINE | ID: mdl-31125491
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Pirimidinas / Inibidores de Proteínas Quinases / Glutationa Transferase Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male / Middle aged Idioma: En Revista: Basic Clin Pharmacol Toxicol Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Pirimidinas / Inibidores de Proteínas Quinases / Glutationa Transferase Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male / Middle aged Idioma: En Revista: Basic Clin Pharmacol Toxicol Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article