The human nephrin Y<sup>1139</sup>RSL motif is essential for podocyte foot process organization and slit diaphragm formation during glomerular development.

Espiritu, Eugenel B; Jiang, Huajun; Moreau-Marquis, Sophie; Sullivan, Mara; Yan, Kunimasa; Beer Stolz, Donna; Sampson, Matthew G; Hukriede, Neil A; Swiatecka-Urban, Agnieszka

The human nephrin Y¹¹³⁹RSL motif is essential for podocyte foot process organization and slit diaphragm formation during glomerular development.

Espiritu, Eugenel B; Jiang, Huajun; Moreau-Marquis, Sophie; Sullivan, Mara; Yan, Kunimasa; Beer Stolz, Donna; Sampson, Matthew G; Hukriede, Neil A; Swiatecka-Urban, Agnieszka.

Afiliação

Espiritu EB; Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15201.
Jiang H; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.
Moreau-Marquis S; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755.
Sullivan M; Department of Nephrology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15201.
Yan K; Department of Pediatrics, Kyorin University School of Medicine, Mitaka, Tokyo 181-8611, Japan, and.
Beer Stolz D; Department of Nephrology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15201.
Sampson MG; Department of Pediatrics-Nephrology University of Michigan Medical School, Ann Arbor, Michigan 48109.
Hukriede NA; Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15201.
Swiatecka-Urban A; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224,. Electronic address: asurban@pitt.edu.

J Biol Chem ; 294(28): 10773-10788, 2019 07 12.

Article em En | MEDLINE | ID: mdl-31152064

Assuntos

Glomérulos Renais/metabolismo; Proteínas de Membrana/metabolismo; Motivos de Aminoácidos; Animais; Linhagem Celular; Membrana Celular/metabolismo; Movimento Celular; Clatrina/metabolismo; Embrião não Mamífero/metabolismo; Endocitose; Humanos; Glomérulos Renais/ultraestrutura; Proteínas de Membrana/antagonistas & inibidores; Proteínas de Membrana/genética; Morfolinos/metabolismo; Mutagênese Sítio-Dirigida; Fosforilação; Podócitos/citologia; Podócitos/metabolismo; Peixe-Zebra/crescimento & desenvolvimento

Palavras-chave

cell adhesion; cell culture; cell surface protein; cell-cell interaction; clathrin; clathrin-dependent endocytosis; endocytosis; foot processes; glomerulus; kidney; nephrin; nephrology; nephrotic syndrome; podocyte; slit diaphragm; zebrafish

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glomérulos Renais / Proteínas de Membrana Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article

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