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Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017.
Clayton, Aled; Buschmann, Dominik; Byrd, J Brian; Carter, David R F; Cheng, Lesley; Compton, Carolyn; Daaboul, George; Devitt, Andrew; Falcon-Perez, Juan Manuel; Gardiner, Chris; Gustafson, Dakota; Harrison, Paul; Helmbrecht, Clemens; Hendrix, An; Hill, Andrew; Hoffman, Andrew; Jones, Jennifer C; Kalluri, Raghu; Kang, Ji Yoon; Kirchner, Benedikt; Lässer, Cecilia; Lawson, Charlotte; Lenassi, Metka; Levin, Carina; Llorente, Alicia; Martens-Uzunova, Elena S; Möller, Andreas; Musante, Luca; Ochiya, Takahiro; Pink, Ryan C; Tahara, Hidetoshi; Wauben, Marca H M; Webber, Jason P; Welsh, Joshua A; Witwer, Kenneth W; Yin, Hang; Nieuwland, Rienk.
Afiliação
  • Clayton A; Tissue Microenvironment Group, School of Medicine, Cardiff University, Cardiff, UK.
  • Buschmann D; Division of Animal Physiology and Immunology, Technical University of Munich and Institute of Human Genetics, University Hospital, LMU Munich, Munich, Germany.
  • Byrd JB; Department of Internal Medicine, University of Michigan, 5570C MSRB II, Ann Arbor, USA.
  • Carter DRF; Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.
  • Cheng L; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
  • Compton C; SkySong Center for Innovation, Arizona State University, Scottsdale, AZ, USA.
  • Daaboul G; nanoView Diagnostics, Boston, MA, USA.
  • Devitt A; School of Life & Health Sciences, Aston University, Birmingham, UK.
  • Falcon-Perez JM; Exosomes Laboratory & Metabolomics Platform, CIC bioGUNE, CIBEREHD, IKERBASQUE Research Foundation, Derio, Spain.
  • Gardiner C; Research Department of Haematology, Haemostasis Research, University College London, London, UK.
  • Gustafson D; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
  • Harrison P; Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
  • Helmbrecht C; Particle Metrix GmbH, Meerbusch, Germany.
  • Hendrix A; Laboratory of Experimental Cancer Research, Department of Radiation Oncology and experimental Cancer Research, Ghent University, Ghent, Belgium; and Cancer Research Institute Ghent, Ghent, Belgium.
  • Hill A; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
  • Hoffman A; Regenerative Medicine Laboratory, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.
  • Jones JC; Department of Vaccine Branch, National Cancer Institute, Bethesda, MD, USA.
  • Kalluri R; Department of Cancer Biology, Metastasis Research Center, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Kang JY; Korea Institute of Science and Technology, Center for Bio-microsystems, Seoul, S. Korea.
  • Kirchner B; Division of Animal Physiology and Immunology, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany.
  • Lässer C; Institute of Medicine at Sahlgrenska Academy Krefting Research Centre University of Gothenburg, Gothenburg, Sweden.
  • Lawson C; Department of Comparative Biomedical Sciences, Royal Veterinary College Royal College Street, London, UK.
  • Lenassi M; Institute of Biochemistry, University of Ljubljana, Ljubljana, Slovenia.
  • Levin C; Afula and The Bruce Rappaport Faculty of Medicine, Emek Medical Center, Technion, Haifa, Israel.
  • Llorente A; Department of Molecular Cell Biology, Oslo University Hospital, Oslo, Norway.
  • Martens-Uzunova ES; Department of Urology, Erasmus MC, Rotterdam, CA, The Netherlands.
  • Möller A; Tumour Microenvironment Laboratory, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Australia.
  • Musante L; Department of Medicine, Division of Nephrology, University of Virginia, Charlottesville, VA, USA.
  • Ochiya T; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
  • Pink RC; Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.
  • Tahara H; Department of Cellular and Molecular Biology, Institute and Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima City, Japan.
  • Wauben MHM; Faculty of Veterinary Medicine, Dept. Biochemistry & Cell Biology, Utrecht University, Utrecht, The Netherlands.
  • Webber JP; Tissue Microenvironment Group, School of Medicine, Cardiff University, Cardiff, UK.
  • Welsh JA; Department of Vaccine Branch, National Cancer Institute, Bethesda, MD, USA.
  • Witwer KW; Department of Molecular and Comparative Pathobiology, Johns Hopkins Institute for NanoBio Technology, Johns Hopkins University, Baltimore, USA.
  • Yin H; School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
  • Nieuwland R; Department Laboratory Experimental Clinical Chemistry, Academic Medical Center, University of Amsterdam, DE, Amsterdam, The Netherlands.
J Extracell Vesicles ; 7(1): 1473707, 2018.
Article em En | MEDLINE | ID: mdl-31162490
ABSTRACT
This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Guideline / Prognostic_studies Idioma: En Revista: J Extracell Vesicles Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Guideline / Prognostic_studies Idioma: En Revista: J Extracell Vesicles Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido