Immunohistochemistry-Enabled Precision Medicine.
Cancer Treat Res
; 178: 111-135, 2019.
Article
em En
| MEDLINE
| ID: mdl-31209843
ABSTRACT
Immunohistochemistry (IHC) can be applied to diagnostic aspects of pathologic examination to provide aid in assignment of lineage and histologic type of cancer. Increasingly, however, IHC is widely used to provide prognostic and predictive (theranostic) information about the neoplastic disease. A refinement of theranostic application of IHC can be seen in the use of "genomic probing" where antibody staining results are directly correlated with an underlying genetic alteration in the tumor (somatic mutations) and/or the patient (germline constitution). All these aspects of IHC find their best use in guiding the oncologists in the optimal use of therapy for the patients.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imuno-Histoquímica
/
Medicina de Precisão
/
Neoplasias
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Cancer Treat Res
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos