A distinct structural mechanism underlies TRPV1 activation by piperine.

Dong, Yawen; Yin, Yue; Vu, Simon; Yang, Fan; Yarov-Yarovoy, Vladimir; Tian, Yuhua; Zheng, Jie

Dong, Yawen; Yin, Yue; Vu, Simon; Yang, Fan; Yarov-Yarovoy, Vladimir; Tian, Yuhua; Zheng, Jie.

Afiliação

Dong Y; Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao, Shandong, China.
Yin Y; Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao, Shandong, China.
Vu S; Department of Physiology and Membrane Biology, UC Davis School of Medicine, Davis, CA, 95616, USA.
Yang F; Department of Biophysics and Kidney Disease Center, First Affiliated Hospital, Institute of Neuroscience, National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.
Yarov-Yarovoy V; Department of Physiology and Membrane Biology, UC Davis School of Medicine, Davis, CA, 95616, USA.
Tian Y; Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao, Shandong, China. Electronic address: yhtian05250@qdu.edu.cn.
Zheng J; Department of Physiology and Membrane Biology, UC Davis School of Medicine, Davis, CA, 95616, USA. Electronic address: jzheng@ucdavis.edu.

Biochem Biophys Res Commun ; 516(2): 365-372, 2019 08 20.

Article em En | MEDLINE | ID: mdl-31213294

Assuntos

Alcaloides/farmacologia; Benzodioxóis/farmacologia; Piperidinas/farmacologia; Alcamidas Poli-Insaturadas/farmacologia; Canais de Cátion TRPV/química; Canais de Cátion TRPV/metabolismo; Alcaloides/química; Animais; Benzodioxóis/química; Capsaicina; Ligação de Hidrogênio; Ativação do Canal Iônico/efeitos dos fármacos; Camundongos; Mutação/genética; Piperidinas/química; Alcamidas Poli-Insaturadas/química; Relação Estrutura-Atividade; Canais de Cátion TRPV/genética

Palavras-chave

Agonist; CPZ; Capsaicin; ECS; Nociception; Pepper; Pungency; Spice; TRPA1; The abbreviations used are; VDW; capsazepine; extracellular solution; mTRPV1; mouse transient receptor potential cation channel, subfamily V, member 1; transient receptor potential cation channel, subfamily A, member 1; van der Waals

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Alcaloides / Benzodioxóis / Canais de Cátion TRPV / Alcamidas Poli-Insaturadas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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