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Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells.
Selka, Ayyoub; Doiron, Jérémie A; Lyons, Pierre; Dastous, Sonia; Chiasson, Alison; Cormier, Marc; Turcotte, Sandra; Surette, Marc E; Touaibia, Mohamed.
Afiliação
  • Selka A; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada.
  • Doiron JA; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada.
  • Lyons P; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada.
  • Dastous S; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada.
  • Chiasson A; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada.
  • Cormier M; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada.
  • Turcotte S; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada.
  • Surette ME; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada.
  • Touaibia M; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick, Canada. Electronic address: mohamed.touaibia@umoncton.ca.
Eur J Med Chem ; 179: 347-357, 2019 Oct 01.
Article em En | MEDLINE | ID: mdl-31260889
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Araquidonato 5-Lipoxigenase / Carcinoma de Células Renais / Inibidores de Lipoxigenase / Apoptose / Descoberta de Drogas / Neoplasias Renais / Antineoplásicos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Canadá
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Araquidonato 5-Lipoxigenase / Carcinoma de Células Renais / Inibidores de Lipoxigenase / Apoptose / Descoberta de Drogas / Neoplasias Renais / Antineoplásicos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Canadá