Metabolome signature of autism in the human prefrontal cortex.
Commun Biol
; 2: 234, 2019.
Article
em En
| MEDLINE
| ID: mdl-31263778
ABSTRACT
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with yet incompletely uncovered molecular determinants. Alterations in the abundance of low molecular weight compounds (metabolites) in ASD could add to our understanding of the disease. Indeed, such alterations take place in the urine, plasma and cerebellum of ASD individuals. In this work, we investigated mass-spectrometric signal intensities of 1,366 metabolites in the prefrontal cortex grey matter of 32 ASD and 40 control individuals. 15% of these metabolites showed significantly different intensities in ASD and clustered in 16 metabolic pathways. Of them, ten pathways were altered in urine and blood of ASD individuals (Fisher test, p < 0.05), opening an opportunity for the design of new diagnostic instruments. Furthermore, metabolic measurements conducted in 40 chimpanzees and 40 macaques showed an excess of metabolite intensity differences unique to humans, supporting the hypothesized disruption of evolutionary novel cortical mechanisms in ASD.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transtorno Autístico
/
Córtex Pré-Frontal
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Metaboloma
Limite:
Animals
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Humans
Idioma:
En
Revista:
Commun Biol
Ano de publicação:
2019
Tipo de documento:
Article