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ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles.
Seo, Wonhyo; Gao, Yanhang; He, Yong; Sun, Jing; Xu, Hongqin; Feng, Dechun; Park, Seol Hee; Cho, Young-Eun; Guillot, Adrien; Ren, Tianyi; Wu, Ruihong; Wang, Jingyun; Kim, Seung-Jin; Hwang, Seonghwan; Liangpunsakul, Suthat; Yang, Yingzi; Niu, Junqi; Gao, Bin.
Afiliação
  • Seo W; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
  • Gao Y; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA; Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun 130021, China.
  • He Y; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
  • Sun J; Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun 130021, China.
  • Xu H; Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun 130021, China.
  • Feng D; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
  • Park SH; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
  • Cho YE; Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
  • Guillot A; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
  • Ren T; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
  • Wu R; Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun 130021, China.
  • Wang J; Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun 130021, China.
  • Kim SJ; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
  • Hwang S; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
  • Liangpunsakul S; Division of Gastroenterology and Hepatology, Department of Medicine, USA; Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis, IN, USA; Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA.
  • Yang Y; Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA.
  • Niu J; Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun 130021, China.
  • Gao B; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: bgao@mail.nih.gov.
J Hepatol ; 71(5): 1000-1011, 2019 11.
Article em En | MEDLINE | ID: mdl-31279903
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Consumo de Bebidas Alcoólicas / DNA Mitocondrial / Carcinoma Hepatocelular / Hepatite B Crônica / Alcoolismo / Carcinogênese / Vesículas Extracelulares / Aldeído-Desidrogenase Mitocondrial / Cirrose Hepática / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Consumo de Bebidas Alcoólicas / DNA Mitocondrial / Carcinoma Hepatocelular / Hepatite B Crônica / Alcoolismo / Carcinogênese / Vesículas Extracelulares / Aldeído-Desidrogenase Mitocondrial / Cirrose Hepática / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos