Progressive dosage compensation during Drosophila embryogenesis is reflected by gene arrangement.
EMBO Rep
; 20(8): e48138, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-31286660
ABSTRACT
In Drosophila melanogaster males, X-chromosome monosomy is compensated by chromosome-wide transcription activation. We found that complete dosage compensation during embryogenesis takes surprisingly long and is incomplete even after 10 h of development. Although the activating dosage compensation complex (DCC) associates with the X-chromosome and MOF acetylates histone H4 early, many genes are not compensated. Acetylation levels on gene bodies continue to increase for several hours after gastrulation in parallel with progressive compensation. Constitutive genes are compensated earlier than developmental genes. Remarkably, later compensation correlates with longer distances to DCC binding sites. This time-space relationship suggests that DCC action on target genes requires maturation of the active chromosome compartment.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cromossomo X
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Mecanismo Genético de Compensação de Dose
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Regulação da Expressão Gênica no Desenvolvimento
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Desenvolvimento Embrionário
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Drosophila melanogaster
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Cromossomos de Insetos
Limite:
Animals
Idioma:
En
Revista:
EMBO Rep
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Alemanha