Stability Evaluation and Stabilization of a Gastrin-Releasing Peptide Receptor (GRPR) Targeting Imaging Pharmaceutical.

Ghosh, Arijit; Woolum, Karen; Kothandaraman, Shankaran; Tweedle, Michael F; Kumar, Krishan

Ghosh, Arijit; Woolum, Karen; Kothandaraman, Shankaran; Tweedle, Michael F; Kumar, Krishan.

Afiliação

Ghosh A; Laboratory for Translational Research in Imaging Pharmaceuticals, Wright Center of Innovation in Biomedical Imaging, Department of Radiology, The Ohio State University, Columbus, OH 43212, USA.
Woolum K; Laboratory for Translational Research in Imaging Pharmaceuticals, Wright Center of Innovation in Biomedical Imaging, Department of Radiology, The Ohio State University, Columbus, OH 43212, USA.
Kothandaraman S; Laboratory for Translational Research in Imaging Pharmaceuticals, Wright Center of Innovation in Biomedical Imaging, Department of Radiology, The Ohio State University, Columbus, OH 43212, USA.
Tweedle MF; Laboratory for Translational Research in Imaging Pharmaceuticals, Wright Center of Innovation in Biomedical Imaging, Department of Radiology, The Ohio State University, Columbus, OH 43212, USA.
Kumar K; Laboratory for Translational Research in Imaging Pharmaceuticals, Wright Center of Innovation in Biomedical Imaging, Department of Radiology, The Ohio State University, Columbus, OH 43212, USA. Krishan.Kumar@osumc.edu.

Molecules ; 24(16)2019 Aug 08.

Article em En | MEDLINE | ID: mdl-31398865

Assuntos

Imagem Molecular; Receptores da Bombesina/química; Animais; Biomarcadores; Cromatografia Líquida de Alta Pressão; Cães; Humanos; Ligantes; Camundongos; Imagem Molecular/métodos; Estrutura Molecular; Estabilidade Proteica; Compostos Radiofarmacêuticos/química; Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz

Palavras-chave

GRPR; acetate buffer stability; canine serum stability; gastrin-releasing peptide receptor; human serum stability; imaging pharmaceuticals; in-vitro stability; mouse serum stability; radiolabeling; radiotracers

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores da Bombesina / Imagem Molecular Limite: Animals / Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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