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Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life.
Liu, Lei; Lauro, Bianca M; Ding, Li; Rovere, Matteo; Wolfe, Michael S; Selkoe, Dennis J.
Afiliação
  • Liu L; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Lauro BM; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Ding L; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Rovere M; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Wolfe MS; Department of Medical Chemistry, University of Kansas School of Pharmacy, Lawrence, KS, USA.
  • Selkoe DJ; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: dselkoe@bwh.harvard.edu.
Alzheimers Dement ; 15(9): 1183-1194, 2019 09.
Article em En | MEDLINE | ID: mdl-31416794
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Ácido Aspártico Endopeptidases / Secretases da Proteína Precursora do Amiloide / Doença de Alzheimer / Imidazóis / Neurônios Limite: Animals / Humans Idioma: En Revista: Alzheimers Dement Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Ácido Aspártico Endopeptidases / Secretases da Proteína Precursora do Amiloide / Doença de Alzheimer / Imidazóis / Neurônios Limite: Animals / Humans Idioma: En Revista: Alzheimers Dement Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos