Maternal Haplotypes in <i>DHFR</i> Promoter and <i>MTHFR</i> Gene in Tuning Childhood Acute Lymphoblastic Leukemia Onset-Latency: Genetic/Epigenetic Mother/Child Dyad Study (GEMCDS).

Tisato, Veronica; Muggeo, Paola; Lupiano, Tracy; Longo, Giovanna; Serino, Maria Luisa; Grassi, Massimo; Arcamone, Ermanno; Secchiero, Paola; Zauli, Giorgio; Santoro, Nicola; Gemmati, Donato

Maternal Haplotypes in DHFR Promoter and MTHFR Gene in Tuning Childhood Acute Lymphoblastic Leukemia Onset-Latency: Genetic/Epigenetic Mother/Child Dyad Study (GEMCDS).

Tisato, Veronica; Muggeo, Paola; Lupiano, Tracy; Longo, Giovanna; Serino, Maria Luisa; Grassi, Massimo; Arcamone, Ermanno; Secchiero, Paola; Zauli, Giorgio; Santoro, Nicola; Gemmati, Donato.

Afiliação

Tisato V; Department of Morphology, Surgery & Experimental Medicine and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy.
Muggeo P; Department of Pediatric Oncology & Hematology, University Hospital Policlinico, 70124 Bari, Italy.
Lupiano T; Department of Biomedical & Specialty Surgical Sciences, and Centre Haemostasis & Thrombosis, University of Ferrara, 44121 Ferrara, Italy.
Longo G; Department of Biomedical & Specialty Surgical Sciences, and Centre Haemostasis & Thrombosis, University of Ferrara, 44121 Ferrara, Italy.
Serino ML; Department of Biomedical & Specialty Surgical Sciences, and Centre Haemostasis & Thrombosis, University of Ferrara, 44121 Ferrara, Italy.
Grassi M; Department of Pediatric Oncology & Hematology, University Hospital Policlinico, 70124 Bari, Italy.
Arcamone E; Department of Pediatric Oncology & Hematology, University Hospital Policlinico, 70124 Bari, Italy.
Secchiero P; Department of Morphology, Surgery & Experimental Medicine and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy.
Zauli G; Department of Morphology, Surgery & Experimental Medicine and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy.
Santoro N; Department of Pediatric Oncology & Hematology, University Hospital Policlinico, 70124 Bari, Italy.
Gemmati D; Department of Biomedical & Specialty Surgical Sciences, and Centre Haemostasis & Thrombosis, University of Ferrara, 44121 Ferrara, Italy. d.gemmati@unife.it.

Genes (Basel) ; 10(9)2019 08 22.

Article em En | MEDLINE | ID: mdl-31443485

Assuntos

Epigênese Genética; Haplótipos; Metilenotetra-Hidrofolato Redutase (NADPH2)/genética; Polimorfismo de Nucleotídeo Único; Leucemia-Linfoma Linfoblástico de Células Precursoras/genética; Tetra-Hidrofolato Desidrogenase/genética; Adulto; Idade de Início; Criança; Pré-Escolar; Feminino; Homozigoto; Humanos; Masculino; Mães; Leucemia-Linfoma Linfoblástico de Células Precursoras/patologia; Regiões Promotoras Genéticas

Palavras-chave

ALL onset; Childhood Acute Lymphoblastic Leukemia; DHFR; MTHFR; MTX; epigenetics; folate; mother-fetus in utero crosstalk; parent-origin effect (POE); polymorphism/gene variant

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tetra-Hidrofolato Desidrogenase / Haplótipos / Polimorfismo de Nucleotídeo Único / Metilenotetra-Hidrofolato Redutase (NADPH2) / Epigênese Genética / Leucemia-Linfoma Linfoblástico de Células Precursoras Limite: Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Genes (Basel) Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Itália

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