Differentiation-inducing factor-1 prevents hepatic stellate cell activation through inhibiting GSK3ß inactivation.

Furukawa, Shohei; Yamaguchi, Momoka; Ooka, Akira; Kikuchi, Haruhisa; Ishikawa, Tomohisa; Saito, Shin-Ya

Furukawa, Shohei; Yamaguchi, Momoka; Ooka, Akira; Kikuchi, Haruhisa; Ishikawa, Tomohisa; Saito, Shin-Ya.

Afiliação

Furukawa S; Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga Ward, Shizuoka City, Shizuoka, 422-8526, Japan; Kyoto Pharmaceutical Industries, Ltd., 38 Nishinokyo, Tsukinowa-cho, Nakagyo-ku, Kyoto, 604-8444, Japan.
Yamaguchi M; Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga Ward, Shizuoka City, Shizuoka, 422-8526, Japan. Electronic address: yamamomo@u-shizuoka-ken.ac.jp.
Ooka A; Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga Ward, Shizuoka City, Shizuoka, 422-8526, Japan.
Kikuchi H; Laboratory of Natural Product Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.
Ishikawa T; Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga Ward, Shizuoka City, Shizuoka, 422-8526, Japan.
Saito SY; Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga Ward, Shizuoka City, Shizuoka, 422-8526, Japan.

Biochem Biophys Res Commun ; 520(1): 140-144, 2019 11 26.

Article em En | MEDLINE | ID: mdl-31582219

Assuntos

Glicogênio Sintase Quinase 3 beta/antagonistas & inibidores; Células Estreladas do Fígado/efeitos dos fármacos; Hexanonas/farmacologia; Transporte Ativo do Núcleo Celular; Adenina/análogos & derivados; Adenina/farmacologia; Animais; Antineoplásicos/farmacologia; Diferenciação Celular; Transdiferenciação Celular; Dictyostelium; Relação Dose-Resposta a Droga; Células Estreladas do Fígado/metabolismo; Cirrose Hepática/metabolismo; Camundongos; Oxidiazóis/farmacologia; Fosforilação; Pirimidinas/farmacologia; Pirróis/farmacologia; Quinoxalinas/farmacologia; Transdução de Sinais; beta Catenina/metabolismo

Palavras-chave

Differentiation-inducing factor-1; Glycogen synthase kinase 3ß; Hepatic stellate cell; Liver fibrosis; Transdifferentiation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Estreladas do Fígado / Glicogênio Sintase Quinase 3 beta / Hexanonas Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão

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