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Urodynamic Mechanisms Underlying Overactive Bladder Symptoms in Patients With Parkinson Disease.
Vurture, Gregory; Peyronnet, Benoit; Palma, Jose-Alberto; Sussman, Rachael D; Malacarne, Dominique R; Feigin, Andrew; Palmerola, Ricardo; Rosenblum, Nirit; Frucht, Steven; Kaufmann, Horacio; Nitti, Victor W; Brucker, Benjamin M.
Afiliação
  • Vurture G; Department of Urology, New York University School of Medicine, New York, NY, USA.
  • Peyronnet B; Department of Urology, New York University School of Medicine, New York, NY, USA.
  • Palma JA; Department of Urology, University of Rennes, Rennes, France.
  • Sussman RD; Department of Neurology Dysautonomia Center, New York University School of Medicine, New York, NY, USA.
  • Malacarne DR; Department of Urology, New York University School of Medicine, New York, NY, USA.
  • Feigin A; Department of Urology, New York University School of Medicine, New York, NY, USA.
  • Palmerola R; The Marlene & Paolo Fresco Institute for Parkinson's & Movement Disorders, New York University School of Medicine, New York, NY, USA.
  • Rosenblum N; Department of Urology, New York University School of Medicine, New York, NY, USA.
  • Frucht S; Department of Urology, New York University School of Medicine, New York, NY, USA.
  • Kaufmann H; The Marlene & Paolo Fresco Institute for Parkinson's & Movement Disorders, New York University School of Medicine, New York, NY, USA.
  • Nitti VW; Department of Neurology Dysautonomia Center, New York University School of Medicine, New York, NY, USA.
  • Brucker BM; Department of Urology, New York University School of Medicine, New York, NY, USA.
Int Neurourol J ; 23(3): 211-218, 2019 Sep.
Article em En | MEDLINE | ID: mdl-31607100
ABSTRACT

PURPOSE:

To assess the urodynamic findings in patients with Parkinson disease (PD) with overactive bladder symptoms.

METHODS:

We performed a retrospective chart review of all PD patients who were seen in an outpatient clinic for lower urinary tract symptoms (LUTS) between 2010 and 2017 in a single-institution. Only patients who complained of overactive bladder (OAB) symptoms and underwent a video-urodynamic study for these symptoms were included. We excluded patients with neurological disorders other than PD and patients with voiding LUTS but without OAB symptoms.

RESULTS:

We included 42 patients (29 men, 13 women, 74.5±8.1 years old). Seven patients (16.7%) had a postvoid residual (PVR) bladder volume >100 mL and only one reported incomplete bladder emptying. Detrusor overactivity (DO) was found in all 42 patients (100%) and was terminal in 19 (45.2%) and phasic in 22 patients (52.4%). Eighteen patients had detrusor underactivity (DU) (42.3%). Later age of PD diagnosis was the only parameter associated with DU (P=0.02). Patients with bladder outlet obstruction (BOO) were younger than patients without BOO (70.1 years vs. 76.5 years, P=0.004), had later first sensation of bladder filling (173.5 mL vs. 120.3 mL, P=0.02) and first involuntary detrusor contraction (226.4 mL vs. 130.4 mL, P=0.009).

CONCLUSION:

DO is almost universal in all patients with PD complaining of OAB symptoms (97.1%). However, a significant percentage of patients also had BOO (36.8%), DU (47%), and increased PVR (16.7%) indicating that neurogenic DO may not be the only cause of OAB symptoms in PD patients.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Int Neurourol J Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Int Neurourol J Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos