GD2-directed CAR-T cells in combination with HGF-targeted neutralizing antibody (AMG102) prevent primary tumor growth and metastasis in Ewing sarcoma.

Charan, Manish; Dravid, Piyush; Cam, Maren; Audino, Anthony; Gross, Amy C; Arnold, Michael A; Roberts, Ryan D; Cripe, Timothy P; Pertsemlidis, Alexander; Houghton, Peter J; Cam, Hakan

Charan, Manish; Dravid, Piyush; Cam, Maren; Audino, Anthony; Gross, Amy C; Arnold, Michael A; Roberts, Ryan D; Cripe, Timothy P; Pertsemlidis, Alexander; Houghton, Peter J; Cam, Hakan.

Afiliação

Charan M; Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, Columbus, OH.
Dravid P; Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, Columbus, OH.
Cam M; Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, Columbus, OH.
Audino A; Division of Hematology, Oncology and Blood and Marrow Transplantation, Nationwide Children's Hospital, Columbus, OH.
Gross AC; Department of Pediatrics, The Ohio State University, Columbus, OH.
Arnold MA; Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, Columbus, OH.
Roberts RD; Department of Pediatrics, The Ohio State University, Columbus, OH.
Cripe TP; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH.
Pertsemlidis A; Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, Columbus, OH.
Houghton PJ; Department of Pediatrics, The Ohio State University, Columbus, OH.
Cam H; Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, Columbus, OH.

Int J Cancer ; 146(11): 3184-3195, 2020 06 01.

Article em En | MEDLINE | ID: mdl-31621900

Assuntos

Anticorpos Monoclonais Humanizados/uso terapêutico; Antineoplásicos Imunológicos/uso terapêutico; Neoplasias Ósseas/tratamento farmacológico; Receptores de Antígenos Quiméricos/imunologia; Sarcoma de Ewing/tratamento farmacológico; Animais; Neoplasias Ósseas/patologia; Linhagem Celular Tumoral; Terapia Baseada em Transplante de Células e Tecidos/métodos; Fator de Crescimento de Hepatócito/metabolismo; Humanos; Imunoterapia Adotiva/métodos; Camundongos; Proteínas Proto-Oncogênicas c-met/antagonistas & inibidores; Proteínas Proto-Oncogênicas c-met/imunologia; Sarcoma de Ewing/patologia; Transdução de Sinais/imunologia; Linfócitos T/imunologia; Microambiente Tumoral/imunologia; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto/métodos

Palavras-chave

AMG102; CAR-T cell therapy; Ewing sarcoma; HGF; delta133p53; metastasis; preclinical studies

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sarcoma de Ewing / Neoplasias Ósseas / Anticorpos Monoclonais Humanizados / Antineoplásicos Imunológicos / Receptores de Antígenos Quiméricos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Int J Cancer Ano de publicação: 2020 Tipo de documento: Article

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