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Management of growth failure and growth hormone deficiency after pediatric allogeneic HSCT: Endocrinologists are of importance for further guidelines and studies.
Lawitschka, A; Schwarze, P; Rovelli, A; Badoglio, M; Socie, G; Tichelli, A; Bauer, D; Rovo, A; Basak, G; Schoemans, H; Peters, C; Salooja, N.
Afiliação
  • Lawitschka A; St. Anna Children's Hospital, Vienna Medical University, Vienna, Austria.
  • Schwarze P; Department of General Pediatrics, Hematology/Oncology, University Children's Hospital, Tuebingen, Germany.
  • Rovelli A; MBBM Foundation, Bone Marrow Transplantation Unit, Pediatric Department of Milano-Bicocca University, Monza, Italy.
  • Badoglio M; Department of Haematology, EBMT Paris Study Office, Saint Antoine Hospital, Paris, France.
  • Socie G; Department of Hematology, Hôpital Saint Louis, Paris, France.
  • Tichelli A; Department for Haematology, University Hospital Basel, Basel, Switzerland.
  • Bauer D; St. Anna Children's Hospital, Vienna Medical University, Vienna, Austria.
  • Rovo A; Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern.
  • Basak G; Department of Hematology, Oncology, and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
  • Schoemans H; Department of Hematology, University Hospital Leuven and KU Leuven, Leuven, Belgium.
  • Peters C; St. Anna Children's Hospital, Vienna Medical University, Vienna, Austria.
  • Salooja N; Centre for Haematology, Imperial College London, London, UK.
Pediatr Hematol Oncol ; 36(8): 494-503, 2019 Nov.
Article em En | MEDLINE | ID: mdl-31633441
ABSTRACT
Growth failure (GF) is a frequent problem after pediatric allogeneic hematopoietic stem cell transplantation (HSCT). Growth hormone deficiency (GHD) occurs in 20 to 85%, but published data on the efficacy of growth hormone treatment (GHT) are conflicting. Currently, there are no recommendations on screening for and treatment of GHD after HSCT. We aimed to describe the management of endocrine follow-up (FU)and details of GHT within European Society for Blood and Marrow Transplantation (EBMT) centers.In a retrospective questionnaire study, all EBMT centers performing pediatric HSCT were invited. Results were evaluated in correlation with the structure of endocrine aftercare (HSCT-clinicians and endocrinologists).The majority of centers (80%) reported endocrine FU by an endocrinologist - either within the HSCT-center or in a separate endocrine clinic. Fifty-four percent reported FU outside of the HSCT-center. As diagnostic tests the insulin-like growth factor IGF-I and insulin-like growth factor binding protein IGFBP3, insulin tolerance test and arginine stimulation test were most frequently used. Sixty-four percent of centers performed GHT and endocrinologists were more likely to prescribe GH (74%) compared to HSCT-clinicians (33%). The most frequent indication for GHT was GHD in 60%, with a distinct different approach of endocrinologists in comparison with HSCT-clinicians.Our study reveals substantial variation in practice and emphasizes the need for endocrine aftercare performed by dedicated endocrinologists in close collaboration with the HSCT-center. Our results indicate that the management of GHT depends on the structure of endocrine aftercare, which is important for the future development and distribution of studies and guidelines.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante Homólogo / Hormônio do Crescimento / Transplante de Células-Tronco Hematopoéticas / Condicionamento Pré-Transplante Tipo de estudo: Guideline / Observational_studies / Qualitative_research Limite: Female / Humans / Male Idioma: En Revista: Pediatr Hematol Oncol Assunto da revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Áustria

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante Homólogo / Hormônio do Crescimento / Transplante de Células-Tronco Hematopoéticas / Condicionamento Pré-Transplante Tipo de estudo: Guideline / Observational_studies / Qualitative_research Limite: Female / Humans / Male Idioma: En Revista: Pediatr Hematol Oncol Assunto da revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Áustria