Risk of chemotherapy-associated liver injury (CALI) in PNPLA3 p.148M allele carriers: Preliminary results of a transient elastography-based study.
Dig Liver Dis
; 52(1): 102-106, 2020 01.
Article
em En
| MEDLINE
| ID: mdl-31669075
ABSTRACT
BACKGROUND AND AIMS:
Liver steatosis is one of the side effects of chemotherapy. The PNPLA3 p.I148M, TM6SF2 p.E167K and MBOAT7 p.G17E variants represent genetic determinants for progressive liver diseases. Here, we investigate their association with chemotherapy-associated steatosis. PATIENTS ANDMETHODS:
Prospectively, we recruited 87 patients undergoing systemic chemotherapy for gastrointestinal cancers. Hepatic fat (controlled attenuation parameter, CAP) and liver stiffness (LSM) were measured non-invasively before the initiation of chemotherapy (T0) and after at least two (T1) and four cycles (T2). Genetic variants were genotyped using allelic discrimination assays.RESULTS:
In the final dataset (nâ¯=â¯60) patients demonstrated the following CAP values T0 - 215.0⯱â¯55.7â¯dB/m, T1 - 223.3⯱â¯53.6â¯dB/m, T2 - 223.4⯱â¯56.7â¯dB/m, consistent with mild steatosis. Initial CAP correlated with BMI (Pâ¯<â¯0.01) and serum triglyceride concentrations (Pâ¯=â¯0.03). Whereas at T0 none of the variants was associated with CAP or LSM, carriers of the prosteatotic PNPLA3 p.148M allele showed significantly (Pâ¯=â¯0.008) higher steatosis at T1 as compared to patients carrying the homozygous wild-type genotype [II].CONCLUSIONS:
Our preliminary results show that patients carrying the PNPLA3 p.I148â¯M risk allele might be prone to hepatic fat accumulation during chemotherapy. Further studies are be needed to validate the clinical value of these findings.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Aciltransferases
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Fígado Gorduroso
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Lipase
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Proteínas de Membrana
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Antineoplásicos
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Dig Liver Dis
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Alemanha