Eupulcherol A, a triterpenoid with a new carbon skeleton from Euphorbia pulcherrima, and its anti-Alzheimer's disease bioactivity.
Org Biomol Chem
; 18(1): 76-80, 2019 12 18.
Article
em En
| MEDLINE
| ID: mdl-31773124
ABSTRACT
Eupulcherol A (1), a novel triterpenoid with an unprecedented carbon skeleton, was isolated from Euphorbia pulcherrima. Its structure was determined by comprehensive analysis of spectroscopic data, including HRESIMS and 1D and 2D NMR, and the absolute configuration was defined by single crystal X-ray diffraction analysis. Biological studies showed that compound 1 possessed anti-Alzheimer's disease (AD) bioactivity, which could delay paralysis of transgenic AD Caenorhabditis elegans. A plausible biogenetic pathway for eupulcherol A (1) was also proposed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
/
Caenorhabditis elegans
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Euphorbia
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Doença de Alzheimer
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Antiprotozoários
Limite:
Animals
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2019
Tipo de documento:
Article