Steroidal saponins from Trillium tschonoskii rhizomes and their cytotoxicity against HepG2 cells.
Steroids
; 156: 108587, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-31982423
ABSTRACT
A phytochemical study on the rhizomes of Trillium tschonoskii led to the isolation of fourteen new steroidal saponins, trillitschosides S1-S14 (1-14), along with ten known analogues (15-24). Their structures were established mainly by spectroscopic analyses as well as necessary chemical evidence. All isolated compounds were screened for the cytotoxicity against HepG2 cells, and the results demonstrated that only the known compounds 21-24 exhibited the remarkable cytotoxic activity against HepG2 cells which is much better than the positive control of 5-FU.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Saponinas
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Esteroides
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Extratos Vegetais
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Trillium
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Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Revista:
Steroids
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China