Estimating the power of sequence covariation for detecting conserved RNA structure.
Bioinformatics
; 36(10): 3072-3076, 2020 05 01.
Article
em En
| MEDLINE
| ID: mdl-32031582
ABSTRACT
Pairwise sequence covariations are a signal of conserved RNA secondary structure. We describe a method for distinguishing when lack of covariation signal can be taken as evidence against a conserved RNA structure, as opposed to when a sequence alignment merely has insufficient variation to detect covariations. We find that alignments for several long non-coding RNAs previously shown to lack covariation support do have adequate covariation detection power, providing additional evidence against their proposed conserved structures. AVAILABILITY AND IMPLEMENTATION The R-scape web server is at eddylab.org/R-scape, with a link to download the source code. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA
/
RNA Longo não Codificante
Idioma:
En
Revista:
Bioinformatics
Assunto da revista:
INFORMATICA MEDICA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos