Acute In Vivo Functional Assessment of a Biodegradable Stentless Elastomeric Tricuspid Valve.
J Cardiovasc Transl Res
; 13(5): 796-805, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32040766
ABSTRACT
Degradable heart valves based on in situ tissue regeneration have been proposed as potentially durable and non-thrombogenic prosthetic alternatives. We evaluated the acute in vivo function, microstructure, mechanics, and thromboresistance of a stentless biodegradable tissue-engineered heart valve (TEHV) in the tricuspid position. Biomimetic stentless tricuspid valves were fabricated with poly(carbonate urethane)urea (PCUU) by double-component deposition (DCD) processing to mimic native valve mechanics and geometry. Five swine then underwent 24-h TEHV implantation in the tricuspid position. Echocardiography demonstrated good leaflet motion and no prolapse and trace to mild regurgitation in all but one animal. Histology revealed patches of proteinaceous deposits with no cellular uptake. SEM demonstrated retained scaffold microarchitecture with proteinaceous deposits but no platelet aggregation or thrombosis. Explanted PCUU leaflet thickness and mechanical anisotropy were comparable with native tricuspid leaflets. Bioinspired, elastomeric, stentless TEHVs fabricated by DCD were readily implantable and demonstrated good acute function in the tricuspid position.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Poliuretanos
/
Valva Tricúspide
/
Próteses Valvulares Cardíacas
/
Implante de Prótese de Valva Cardíaca
/
Elastômeros
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
J Cardiovasc Transl Res
Assunto da revista:
ANGIOLOGIA
/
CARDIOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos