A Promising New Anti-Cancer Strategy: Iron Chelators Targeting CSCs.
Acta Med Okayama
; 74(1): 1-6, 2020 Feb.
Article
em En
| MEDLINE
| ID: mdl-32099242
ABSTRACT
Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quelantes de Ferro
/
Ferro
/
Neoplasias
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Acta Med Okayama
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Japão