Skin microbial landscape and immune-endocrine parameters in patients with psoriasis by using narrowband UVB phototherapy.

ABSTRACT

OBJECTIVE: The aim: The study of skin microbial landscape and immune-endocrine parameters as well as improvement of treatment efficiency in patients with different clinical course of psoriasis by using narrowband UVB phototherapy. PATIENTS AND METHODS: Materials and methods: We examined 89 patients with psoriasis (51 men and 38 women) aged 18-60. The comparison group consisted of 43 psoriasis patients comparable by age, sex and clinical course with those from the main group (46 patients). Cytokine levels IL-4, IL-8, IL-10, TNFα, thyroid peroxidase (TPO) and thyroglobulin (Tg) autoantibodies and microbial flora of skin were determined in patients with psoriasis. RESULTS: Results: The study finds that conventional therapy does not have sufficient corrective impact on immune-endocrine disorders and the use of narrow-band light therapy has shown that it has a focused corrective impact on cytokine production and modulating effect on the level of TPO and Tg autoantibodies and the state of skin automicroflora of lesions in patients suffering from psoriasis. CONCLUSION: Conclusions: Using UVB (311 nm) therapy in patients with psoriasis allows improving efficiency of treatment and limiting clinical signs in the form of achieving remission and significant improvement in patients' health without any negative dynamic changes.