The FKH domain in FOXP3 mRNA frequently contains mutations in hepatocellular carcinoma that influence the subcellular localization and functions of FOXP3.

Ren, Jianwei; Liu, Yi; Wang, Shanshan; Wang, Yu; Li, Wende; Chen, Siyu; Cui, Dexuan; Yang, Shengli; Li, Ming-Yue; Feng, Bo; Lai, Paul B S; Chen, George G

Ren, Jianwei; Liu, Yi; Wang, Shanshan; Wang, Yu; Li, Wende; Chen, Siyu; Cui, Dexuan; Yang, Shengli; Li, Ming-Yue; Feng, Bo; Lai, Paul B S; Chen, George G.

Afiliação

Ren J; Department of Surgery, Chinese University of Hong Kong, Hong Kong, China; Shenzhen Research Institute (SZRI), Chinese University of Hong Kong, Shenzhen 518057, China.
Liu Y; Department of Surgery, Chinese University of Hong Kong, Hong Kong, China; Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang, Guangdong 524023, China.
Wang S; School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Wang Y; Division of Cellular & Molecular Research, National Cancer Centre, Singapore 169610.
Li W; Guangdong Laboratory Animals Monitoring Institute, Guangzhou 510663, China.
Chen S; Guangdong Laboratory Animals Monitoring Institute, Guangzhou 510663, China.
Cui D; School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China.
Yang S; Union Hospital Tumour Center, Wuhan 430022, China.
Li MY; Department of Surgery, Chinese University of Hong Kong, Hong Kong, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510320, China.
Feng B; School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China.
Lai PBS; Department of Surgery, Chinese University of Hong Kong, Hong Kong, China. Electronic address: paullai@surgery.cuhk.edu.hk.
Chen GG; Department of Surgery, Chinese University of Hong Kong, Hong Kong, China; Shenzhen Research Institute (SZRI), Chinese University of Hong Kong, Shenzhen 518057, China; Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang, Guangdong 524023, Ch

J Biol Chem ; 295(16): 5484-5495, 2020 04 17.

Article em En | MEDLINE | ID: mdl-32198183

Assuntos

Carcinoma Hepatocelular/genética; Núcleo Celular/metabolismo; Fatores de Transcrição Forkhead/genética; Neoplasias Hepáticas/genética; Mutação; RNA Mensageiro/genética; Transporte Ativo do Núcleo Celular; Animais; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/patologia; Feminino; Fatores de Transcrição Forkhead/química; Fatores de Transcrição Forkhead/metabolismo; Hepatócitos/metabolismo; Humanos; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patologia; Células MCF-7; Masculino; Camundongos; Camundongos SCID; Pessoa de Meia-Idade; Domínios Proteicos; RNA Mensageiro/metabolismo

Palavras-chave

FKH domain; forkhead box P3 (FOXP3); gene transcription; hepatocellular carcinoma (HCC); liver cancer; mutagenesis; mutations; signal transduction; subcellular location; suppression; transcription factor; transcriptional mutagenesis; translocation; tumor suppressor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Núcleo Celular / Carcinoma Hepatocelular / Fatores de Transcrição Forkhead / Neoplasias Hepáticas / Mutação Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Biol Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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