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PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72.
Vieweg, Sophie; Mulholland, Katie; Bräuning, Bastian; Kachariya, Nitin; Lai, Yu-Chiang; Toth, Rachel; Singh, Pawan Kishor; Volpi, Ilaria; Sattler, Michael; Groll, Michael; Itzen, Aymelt; Muqit, Miratul M K.
Afiliação
  • Vieweg S; Department of Chemistry, Centre for Integrated Protein Science Munich (CIPSM), Technical University of Munich, Garching 85748, Germany.
  • Mulholland K; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, U.K.
  • Bräuning B; Department of Chemistry, Centre for Integrated Protein Science Munich (CIPSM), Technical University of Munich, Garching 85748, Germany.
  • Kachariya N; Department of Chemistry, Centre for Integrated Protein Science Munich (CIPSM), Technical University of Munich, Garching 85748, Germany.
  • Lai YC; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, U.K.
  • Toth R; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, U.K.
  • Singh PK; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, U.K.
  • Volpi I; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, U.K.
  • Sattler M; Department of Chemistry, Centre for Integrated Protein Science Munich (CIPSM), Technical University of Munich, Garching 85748, Germany.
  • Groll M; Institute of Structural Biology, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
  • Itzen A; Department of Chemistry, Centre for Integrated Protein Science Munich (CIPSM), Technical University of Munich, Garching 85748, Germany.
  • Muqit MMK; Department of Chemistry, Centre for Integrated Protein Science Munich (CIPSM), Technical University of Munich, Garching 85748, Germany.
Biochem J ; 477(9): 1651-1668, 2020 05 15.
Article em En | MEDLINE | ID: mdl-32227113
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosforilação / Proteínas Quinases / Proteínas rab de Ligação ao GTP / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Biochem J Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosforilação / Proteínas Quinases / Proteínas rab de Ligação ao GTP / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Biochem J Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha