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The inducible ß5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient ß-cells and is overexpressed in type 2 diabetes pancreatic islets.
Khilji, Muhammad Saad; Bresson, Sophie Emilie; Verstappen, Danielle; Pihl, Celina; Andersen, Phillip Alexander Keller; Agergaard, Jette Bach; Dahlby, Tina; Bryde, Tenna Holgersen; Klindt, Kristian; Nielsen, Christian Kronborg; Walentinsson, Anna; Zivkovic, Dusan; Bousquet, Marie-Pierre; Tyrberg, Björn; Richardson, Sarah J; Morgan, Noel G; Mandrup-Poulsen, Thomas; Marzec, Michal Tomasz.
Afiliação
  • Khilji MS; Laboratory of Immuno-endocrinology, Inflammation, Metabolism, and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Bresson SE; Laboratory of Immuno-endocrinology, Inflammation, Metabolism, and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Verstappen D; Laboratory of Immuno-endocrinology, Inflammation, Metabolism, and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Pihl C; Radboud Universiteit, Nijmegen, The Netherlands.
  • Andersen PAK; Laboratory of Immuno-endocrinology, Inflammation, Metabolism, and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Agergaard JB; Laboratory of Immuno-endocrinology, Inflammation, Metabolism, and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Dahlby T; Laboratory of Immuno-endocrinology, Inflammation, Metabolism, and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Bryde TH; Laboratory of Immuno-endocrinology, Inflammation, Metabolism, and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Klindt K; Laboratory of Immuno-endocrinology, Inflammation, Metabolism, and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Nielsen CK; Laboratory of Immuno-endocrinology, Inflammation, Metabolism, and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Walentinsson A; Laboratory of Immuno-endocrinology, Inflammation, Metabolism, and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Zivkovic D; Translational Science and Experimental Medicine, Early Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Bousquet MP; Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, Université de Toulouse, Toulouse, France.
  • Tyrberg B; Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, Université de Toulouse, Toulouse, France.
  • Richardson SJ; Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Morgan NG; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, United Kingdom.
  • Mandrup-Poulsen T; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, United Kingdom.
  • Marzec MT; Laboratory of Immuno-endocrinology, Inflammation, Metabolism, and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Am J Physiol Endocrinol Metab ; 318(6): E892-E900, 2020 06 01.
Article em En | MEDLINE | ID: mdl-32255680
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proinsulina / Complexo de Endopeptidases do Proteassoma / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Degradação Associada com o Retículo Endoplasmático / Estresse do Retículo Endoplasmático / Secreção de Insulina Limite: Animals / Female / Humans / Middle aged Idioma: En Revista: Am J Physiol Endocrinol Metab Assunto da revista: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Dinamarca
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proinsulina / Complexo de Endopeptidases do Proteassoma / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Degradação Associada com o Retículo Endoplasmático / Estresse do Retículo Endoplasmático / Secreção de Insulina Limite: Animals / Female / Humans / Middle aged Idioma: En Revista: Am J Physiol Endocrinol Metab Assunto da revista: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Dinamarca