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Immune complex disease in a chronic monkey study with a humanised, therapeutic antibody against CCL20 is associated with complement-containing drug aggregates.
Laffan, Susan B; Thomson, Andrew S; Mai, Shing; Fishman, Cindy; Kambara, Takahito; Nistala, Kiran; Raymond, James T; Chen, Shugui; Ramani, Thulasi; Pageon, Laura; Polsky, Rodd; Watkins, Mark; Ottolangui, Gemma; White, John R; Maier, Curtis; Herdman, Michael; Bouma, Gerben.
Afiliação
  • Laffan SB; In vitro In vivo Translation (IVIVT), R&D, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America.
  • Thomson AS; Biopharm Analytical Science, R&D Platform Technology and Science, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America.
  • Mai S; Biopharm Analytical Science, R&D Platform Technology and Science, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America.
  • Fishman C; In vitro In vivo Translation (IVIVT), R&D, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America.
  • Kambara T; Pathology, IVIVT, R&D, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America.
  • Nistala K; Adaptive Immunity Research Unit, GlaxoSmithKline, Stevenage, United Kingdom.
  • Raymond JT; Charles River Laboratories, Inc., Frederick, Maryland, United States of America.
  • Chen S; Biopharm Analytical Science, R&D Platform Technology and Science, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America.
  • Ramani T; Envigo CRS, Inc., Princeton, New Jersey, United States of America.
  • Pageon L; Envigo CRS, Inc., Princeton, New Jersey, United States of America.
  • Polsky R; Biopharm Analytical Science, R&D Platform Technology and Science, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America.
  • Watkins M; In vitro In vivo Translation (IVIVT), R&D, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America.
  • Ottolangui G; Biopharm Molecular Discovery, R&D Platform Technology and Science, GlaxoSmithKline, Stevenage, United Kingdom.
  • White JR; Biopharm Analytical Science, R&D Platform Technology and Science, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America.
  • Maier C; In vitro In vivo Translation (IVIVT), R&D, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America.
  • Herdman M; Clinical Pharmacology and Experimental Medicine, GlaxoSmithKline, Stevenage, United Kingdom.
  • Bouma G; Adaptive Immunity Research Unit, GlaxoSmithKline, Stevenage, United Kingdom.
PLoS One ; 15(4): e0231655, 2020.
Article em En | MEDLINE | ID: mdl-32325480
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas do Sistema Complemento / Doenças do Complexo Imune / Imunoconjugados / Quimiocina CCL20 / Anticorpos Monoclonais Humanizados / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas do Sistema Complemento / Doenças do Complexo Imune / Imunoconjugados / Quimiocina CCL20 / Anticorpos Monoclonais Humanizados / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos