FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells.

Saffie, Rizwan; Zhou, Nan; Rolland, Delphine; Önder, Özlem; Basrur, Venkatesha; Campbell, Sydney; Wellen, Kathryn E; Elenitoba-Johnson, Kojo S J; Capell, Brian C; Busino, Luca

Saffie, Rizwan; Zhou, Nan; Rolland, Delphine; Önder, Özlem; Basrur, Venkatesha; Campbell, Sydney; Wellen, Kathryn E; Elenitoba-Johnson, Kojo S J; Capell, Brian C; Busino, Luca.

Afiliação

Saffie R; Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Zhou N; Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Rolland D; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Önder Ö; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Basrur V; Department of Pathology and Clinical Laboratories, University of Michigan, Ann Arbor, Michigan.
Campbell S; Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Wellen KE; Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Elenitoba-Johnson KSJ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Capell BC; Penn Epigenetics Institute, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Busino L; Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Cancer Res ; 80(12): 2498-2511, 2020 06 15.

Article em En | MEDLINE | ID: mdl-32350066

Assuntos

Proteínas de Ligação a DNA/metabolismo; Proteína 7 com Repetições F-Box-WD/metabolismo; Regulação Neoplásica da Expressão Gênica; Linfoma Difuso de Grandes Células B/genética; Proteínas de Neoplasias/metabolismo; Animais; Linhagem Celular Tumoral; Proliferação de Células/genética; Cromatina/metabolismo; Proteínas de Ligação a DNA/genética; Proteína 7 com Repetições F-Box-WD/genética; Feminino; Técnicas de Inativação de Genes; Células HEK293; Humanos; Linfoma Difuso de Grandes Células B/patologia; Camundongos; Proteínas de Neoplasias/genética; Fosforilação Oxidativa; Proteólise; RNA Interferente Pequeno/metabolismo; Transdução de Sinais/genética; Ubiquitina/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Linfoma Difuso de Grandes Células B / Proteínas de Ligação a DNA / Proteína 7 com Repetições F-Box-WD / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cancer Res Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google