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Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation.
Kolijn, Detmar; Pabel, Steffen; Tian, Yanna; Lódi, Mária; Herwig, Melissa; Carrizzo, Albino; Zhazykbayeva, Saltanat; Kovács, Árpád; Fülöp, Gábor Á; Falcão-Pires, Inês; Reusch, Peter H; Linthout, Sophie Van; Papp, Zoltán; van Heerebeek, Loek; Vecchione, Carmine; Maier, Lars S; Ciccarelli, Michele; Tschöpe, Carsten; Mügge, Andreas; Bagi, Zsolt; Sossalla, Samuel; Hamdani, Nazha.
Afiliação
  • Kolijn D; Department of Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany.
  • Pabel S; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Tian Y; Institute of Physiology, Ruhr University Bochum, Bochum, Germany.
  • Lódi M; Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.
  • Herwig M; Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • Carrizzo A; Department of Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany.
  • Zhazykbayeva S; Institute of Physiology, Ruhr University Bochum, Bochum, Germany.
  • Kovács Á; Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
  • Fülöp GÁ; Department of Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany.
  • Falcão-Pires I; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Reusch PH; Institute of Physiology, Ruhr University Bochum, Bochum, Germany.
  • Linthout SV; Vascular Pathophysiology Unit - I.R.C.C.S. Neuromed, 86077, Pozzilli (IS), Italy.
  • Papp Z; Department of Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany.
  • van Heerebeek L; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Vecchione C; Institute of Physiology, Ruhr University Bochum, Bochum, Germany.
  • Maier LS; Department of Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany.
  • Ciccarelli M; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
  • Tschöpe C; Department of Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany.
  • Mügge A; Department of Surgery and Physiology, University of Porto, Porto, Portugal.
  • Bagi Z; Department of Clinical Pharmacology, Ruhr University Bochum, Bochum, Germany.
  • Sossalla S; Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité, University Medicine Berlin, Campus Virchow Clinic, Berlin, Germany.
  • Hamdani N; Department of Cardiology and Pneumology, Charité, University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany.
Cardiovasc Res ; 117(2): 495-507, 2021 01 21.
Article em En | MEDLINE | ID: mdl-32396609
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Volume Sistólico / Compostos Benzidrílicos / Função Ventricular Esquerda / Estresse Oxidativo / Mediadores da Inflamação / Miócitos Cardíacos / Células Endoteliais / Proteína Quinase Dependente de GMP Cíclico Tipo I / Inibidores do Transportador 2 de Sódio-Glicose / Glucosídeos Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cardiovasc Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Volume Sistólico / Compostos Benzidrílicos / Função Ventricular Esquerda / Estresse Oxidativo / Mediadores da Inflamação / Miócitos Cardíacos / Células Endoteliais / Proteína Quinase Dependente de GMP Cíclico Tipo I / Inibidores do Transportador 2 de Sódio-Glicose / Glucosídeos Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cardiovasc Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha