Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow.
Nat Commun
; 11(1): 2570, 2020 05 22.
Article
em En
| MEDLINE
| ID: mdl-32444631
ABSTRACT
At present, it is not clear how memory B lymphocytes are maintained over time, and whether only as circulating cells or also residing in particular tissues. Here we describe distinct populations of isotype-switched memory B lymphocytes (Bsm) of murine spleen and bone marrow, identified according to individual transcriptional signature and B cell receptor repertoire. A population of marginal zone-like cells is located exclusively in the spleen, while a population of quiescent Bsm is found only in the bone marrow. Three further resident populations, present in spleen and bone marrow, represent transitional and follicular B cells and B1 cells, respectively. A population representing 10-20% of spleen and bone marrow memory B cells is the only one qualifying as circulating. In the bone marrow, all cells individually dock onto VCAM1+ stromal cells and, reminiscent of resident memory T and plasma cells, are void of activation, proliferation and mobility.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Baço
/
Células da Medula Óssea
/
Linfócitos B
/
Switching de Imunoglobulina
/
Memória Imunológica
Limite:
Animals
Idioma:
En
Revista:
Nat Commun
Assunto da revista:
BIOLOGIA
/
CIENCIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Alemanha