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Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1.
Liu, Yuan; Lear, Travis B; Verma, Manish; Wang, Kent Zq; Otero, P Anthony; McKelvey, Alison C; Dunn, Sarah R; Steer, Erin; Bateman, Nicholas W; Wu, Christine; Jiang, Yu; Weathington, Nathaniel M; Rojas, Mauricio; Chu, Charleen T; Chen, Bill B; Mallampalli, Rama K.
Afiliação
  • Liu Y; Department of Medicine, the Acute Lung Injury Center of Excellence.
  • Lear TB; The McGowan Institute for Regenerative Medicine.
  • Verma M; Department of Medicine, the Acute Lung Injury Center of Excellence.
  • Wang KZ; Department of Environmental and Occupational Health, Graduate School of Public Health, and.
  • Otero PA; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • McKelvey AC; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Dunn SR; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Steer E; Department of Medicine, the Acute Lung Injury Center of Excellence.
  • Bateman NW; Department of Medicine, the Acute Lung Injury Center of Excellence.
  • Wu C; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Jiang Y; Department of Cell Biology and.
  • Weathington NM; Department of Cell Biology and.
  • Rojas M; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Chu CT; Department of Medicine, the Acute Lung Injury Center of Excellence.
  • Chen BB; Department of Medicine, the Acute Lung Injury Center of Excellence.
  • Mallampalli RK; The McGowan Institute for Regenerative Medicine.
JCI Insight ; 5(11)2020 06 04.
Article em En | MEDLINE | ID: mdl-32493843

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Quinases / Fármacos Neuroprotetores / Proteínas Mitocondriais / Proteínas F-Box / Ubiquitinação / Proteólise Limite: Animals / Humans Idioma: En Revista: JCI Insight Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Quinases / Fármacos Neuroprotetores / Proteínas Mitocondriais / Proteínas F-Box / Ubiquitinação / Proteólise Limite: Animals / Humans Idioma: En Revista: JCI Insight Ano de publicação: 2020 Tipo de documento: Article