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Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction.
Wang, Mingxiang; Li, Jin; Dong, Shunni; Cai, Xiaobo; Simaiti, Aili; Yang, Xin; Zhu, Xinqiang; Luo, Jianhong; Jiang, Lin-Hua; Du, Binyang; Yu, Peilin; Yang, Wei.
Afiliação
  • Wang M; Department of Toxicology, and Department of Medical Oncology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.
  • Li J; Department of Toxicology, and Department of Medical Oncology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.
  • Dong S; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science & Engineering, Zhejiang University, Hangzhou, China.
  • Cai X; Department of Toxicology, and Department of Medical Oncology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.
  • Simaiti A; Department of Biophysics, and Department of Neurosurgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.
  • Yang X; Department of Toxicology, and Department of Medical Oncology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.
  • Zhu X; Department of Toxicology, and Department of Medical Oncology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.
  • Luo J; Department of Toxicology, and Department of Medical Oncology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.
  • Jiang LH; The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, P. R. China.
  • Du B; Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, P. R. China.
  • Yu P; Sino-UK Joint Laboratory of Brain Function and Injury and Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, P. R. China.
  • Yang W; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.
Part Fibre Toxicol ; 17(1): 23, 2020 06 08.
Article em En | MEDLINE | ID: mdl-32513195
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia / Autofagia / Poli(ADP-Ribose) Polimerases / Espécies Reativas de Oxigênio / Dióxido de Silício / Canais de Cátion TRPM / Nanopartículas / Lisossomos Limite: Animals Idioma: En Revista: Part Fibre Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia / Autofagia / Poli(ADP-Ribose) Polimerases / Espécies Reativas de Oxigênio / Dióxido de Silício / Canais de Cátion TRPM / Nanopartículas / Lisossomos Limite: Animals Idioma: En Revista: Part Fibre Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2020 Tipo de documento: Article