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Stimuli-Responsive Cycloaurated "OFF-ON" Switchable Anion Transporters.
Fares, Mohamed; Wu, Xin; Ramesh, Deepthi; Lewis, William; Keller, Paul A; Howe, Ethan N W; Pérez-Tomás, Ricardo; Gale, Philip A.
Afiliação
  • Fares M; School of Chemistry, The University of Sydney, Sydney, New South Wales, 2006, Australia.
  • Wu X; School of Chemistry & Molecular Bioscience, Molecular Horizons, University of Wollongong, Illawarra Health & Medical Research Institute, Wollongong, NSW, 2522, Australia.
  • Ramesh D; School of Chemistry, The University of Sydney, Sydney, New South Wales, 2006, Australia.
  • Lewis W; Faculty of Medicine & Health Sciences, Department of Pathology and Experimental Therapeutics, Cancer Cell Biology Research Group, University of Barcelona, Barcelona, Spain.
  • Keller PA; School of Chemistry, The University of Sydney, Sydney, New South Wales, 2006, Australia.
  • Howe ENW; School of Chemistry & Molecular Bioscience, Molecular Horizons, University of Wollongong, Illawarra Health & Medical Research Institute, Wollongong, NSW, 2522, Australia.
  • Pérez-Tomás R; School of Chemistry, The University of Sydney, Sydney, New South Wales, 2006, Australia.
  • Gale PA; GlaxoSmithKline, GSK Jurong, 1 Pioneer Sector 1, Singapore, 628413, Singapore.
Angew Chem Int Ed Engl ; 59(40): 17614-17621, 2020 09 28.
Article em En | MEDLINE | ID: mdl-32583552
ABSTRACT
Anion transporters have shown potential application as anti-cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes of anion transporters that are "switched on" in situ in the presence of the reducing agent GSH by decomplexation of gold. GSH is found in higher concentrations in tumors than in healthy tissue and hence this approach offers a strategy to target these systems to tumors.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transportadores de Ânions Orgânicos / Ouro Limite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transportadores de Ânions Orgânicos / Ouro Limite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália